Chapter title |
Use of Mouse Models in Atherosclerosis Research
|
---|---|
Chapter number | 1 |
Book title |
Methods in Mouse Atherosclerosis
|
Published in |
Methods in molecular biology, January 2015
|
DOI | 10.1007/978-1-4939-2929-0_1 |
Pubmed ID | |
Book ISBNs |
978-1-4939-2928-3, 978-1-4939-2929-0
|
Authors |
Godfrey S. Getz, Catherine A. Reardon, Getz, Godfrey S., Reardon, Catherine A. |
Abstract |
Cardiovascular disease is the major cause of death in most developed nations and the social and economic burden of this disease is quite high. Atherosclerosis is a major underlying basis for most cardiovascular diseases including myocardial infarction and stroke. Genetically modified mouse models, particularly mice deficient in apoprotein E or the LDL receptor, have been widely used in preclinical atherosclerosis studies to gain insight into the mechanisms underlying this pathology. This chapter reviews several mouse models of atherosclerosis progression and regression as well as the role of immune cells in disease progression and the genetics of murine atherogenesis. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 30 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 5 | 17% |
Student > Bachelor | 3 | 10% |
Researcher | 3 | 10% |
Student > Ph. D. Student | 3 | 10% |
Student > Doctoral Student | 2 | 7% |
Other | 5 | 17% |
Unknown | 9 | 30% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 9 | 30% |
Medicine and Dentistry | 6 | 20% |
Agricultural and Biological Sciences | 2 | 7% |
Nursing and Health Professions | 1 | 3% |
Unspecified | 1 | 3% |
Other | 2 | 7% |
Unknown | 9 | 30% |