Chapter title |
A Model of Systemic Inflammation to Study Neuroinflammation
|
---|---|
Chapter number | 27 |
Book title |
Neurotrophic Factors
|
Published in |
Methods in molecular biology, January 2018
|
DOI | 10.1007/978-1-4939-7571-6_27 |
Pubmed ID | |
Book ISBNs |
978-1-4939-7570-9, 978-1-4939-7571-6
|
Authors |
Vincenzo Sorrenti, Pietro Giusti, Morena Zusso, Sorrenti, Vincenzo, Giusti, Pietro, Zusso, Morena |
Abstract |
Increasing evidence suggests that neurodegeneration occurs in part because the environment is affected during disease in a cascade of processes collectively termed neuroinflammation. This is a reactive response of the central nervous system against noxious elements that interfere with tissue homeostasis. Neuroinflammation is mediated by inflammatory molecules released by microglial cells. Understanding and controlling interactions between the immune system and microglial activation might represent the key to prevent or delay the onset of central nervous system diseases. This chapter details techniques to generate and characterize an in vivo model of neuroinflammation based on a single intraperitoneal injection of lipopolysaccharide, which can be used to understand the wide variety of cellular and molecular mechanisms of neuroinflammation, as well as to identify new therapies by testing the anti-inflammatory properties of synthetic and natural molecules. |
X Demographics
Geographical breakdown
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 19 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 3 | 16% |
Researcher | 3 | 16% |
Student > Master | 3 | 16% |
Student > Bachelor | 1 | 5% |
Professor | 1 | 5% |
Other | 3 | 16% |
Unknown | 5 | 26% |
Readers by discipline | Count | As % |
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Neuroscience | 6 | 32% |
Medicine and Dentistry | 3 | 16% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 11% |
Agricultural and Biological Sciences | 1 | 5% |
Biochemistry, Genetics and Molecular Biology | 1 | 5% |
Other | 2 | 11% |
Unknown | 4 | 21% |