| Chapter title |
Cartilage Tissue Engineering
|
|---|---|
| Chapter number | 16 |
| Book title |
Cartilage Tissue Engineering
|
| Published in |
Methods in molecular biology, January 2015
|
| DOI | 10.1007/978-1-4939-2938-2_16 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-2937-5, 978-1-4939-2938-2
|
| Authors |
Shahin, Kifah, Doran, Pauline M, Doran, Pauline M., Kifah Shahin, Pauline M. Doran |
| Abstract |
Mechanical forces, including hydrodynamic shear, hydrostatic pressure, compression, tension, and friction, can have stimulatory effects on cartilage synthesis in tissue engineering systems. Bioreactors capable of exerting forces on cells and tissue constructs within a controlled culture environment are needed to provide appropriate mechanical stimuli. In this chapter, we describe the construction, assembly, and operation of a mechanobioreactor providing simultaneous dynamic shear and compressive loading on developing cartilage tissues to mimic the rolling and squeezing action of articular joints. The device is suitable for studying the effects of mechanical treatment on stem cells and chondrocytes seeded into three-dimensional scaffolds. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 32 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 11 | 34% |
| Student > Bachelor | 6 | 19% |
| Student > Master | 6 | 19% |
| Researcher | 4 | 13% |
| Professor | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 3 | 9% |
| Readers by discipline | Count | As % |
|---|---|---|
| Engineering | 10 | 31% |
| Biochemistry, Genetics and Molecular Biology | 10 | 31% |
| Agricultural and Biological Sciences | 3 | 9% |
| Medicine and Dentistry | 3 | 9% |
| Chemical Engineering | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 4 | 13% |