Cell surface receptor for ecotropic host-range mouse retroviruses: a cationic amino acid transporter.
Positive-Strand RNA Viruses
Archives of virology Supplementum, January 1994
M. P. Kavanaugh, H. Wang, C. A. R. Boyd, R. A. North, D. Kabat, Kavanaugh, M. P., Wang, H., Boyd, C. A. R., North, R. A., Kabat, D.
The cell surface receptor for ecotropic host-range murine leukemia viruses is a sodium-independent transporter for essential cationic acids. Our evidence strongly identifies this receptor as the transporter system y+, which was previously characterized by transport assays. Mutational analysis indicates that transporter activity is not necessary for viral reception. Infection of cells with ecotropic retroviruses causes only a partial down-modulation of receptor expression on cell surfaces.
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