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Positive-Strand RNA Viruses

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Cover of 'Positive-Strand RNA Viruses'

Table of Contents

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    Book Overview
  2. Altmetric Badge
    Chapter 1 The importance of antigenic variation in vaccine design
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    Chapter 2 The genetic and functional basis of HIV-1 resistance to nonnucleoside reverse transcriptase inhibitors.
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    Chapter 3 Structure-based design of symmetric inhibitors of HIV-1 protease
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    Chapter 4 Age-dependent susceptibility to fatal encephalitis: alphavirus infection of neurons.
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    Chapter 5 Principles and background for the construction of transgenic plants displaying multiple virus resistance
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    Chapter 6 The structure of an immunodominant loop on foot and mouth disease virus, serotype O1, determined under reducing conditions.
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    Chapter 7 Immunopathologic mechanisms of dengue hemorrhagic fever and dengue shock syndrome.
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    Chapter 8 Cardioviral poly(C) tracts and viral pathogenesis.
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    Chapter 9 Transgenic mice and the pathogenesis of poliomyelitis.
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    Chapter 10 Adaptation of positive-strand RNA viruses to plants
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    Chapter 11 A molecular genetic approach to the study of Venezuelan equine encephalitis virus pathogenesis
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    Chapter 12 Use of drug-resistance mutants to identify functional regions in picornavirus capsid proteins. - PubMed - NCBI
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    Chapter 13 Flock house virus: a simple model for studying persistent infection in cultured Drosophila cells.
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    Chapter 14 Protein-protein interactions and glycerophospholipids in bromovirus and nodavirus RNA replication
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    Chapter 15 Characteristics of the poliovirus replication complex
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    Chapter 16 Secretory pathway function, but not cytoskeletal integrity, is required in poliovirus infection.
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    Chapter 17 Role of subgenomic minus-strand RNA in coronavirus replication
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    Chapter 18 Common replication strategies emerging from the study of diverse groups of positive-strand RNA viruses
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    Chapter 19 Preferential replication of defective turnip yellow mosaic virus RNAs that express the 150-kDa protein in cis
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    Chapter 20 In vivo transfection by hepatitis A virus synthetic RNA.
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    Chapter 21 Recombination between Sindbis virus RNAs
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    Chapter 22 Homologous RNA recombination allows efficient introduction of site-specific mutations into the genome of coronavirus MHV-A59 via synthetic co-replicating RNAs
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    Chapter 23 Targeting of the site of nonhomologous genetic recombination in brome mosaic virus
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    Chapter 24 Natural recombination in bovine viral diarrhea viruses
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    Chapter 25 Sequences at the ends of RNA-2 of I6, a recombinant tobravirus
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    Chapter 26 Identification and characterization of host factor interactions with cis -acting elements of rubella virus RNA
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    Chapter 27 Interaction of cellular proteins with the poliovirus 5′ noncoding region
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    Chapter 28 IRES-controlled protein synthesis and genome replication of poliovirus.
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    Chapter 29 Analysis of hepatitis A virus translation in a T7 polymerase-expressing cell line
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    Chapter 30 Purification and characterization of the U-particle, a cellular constituent whose synthesis is stimulated by Mengovirus infection
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    Chapter 31 B-lymphocytes are predominantely involved in viral propagation of hepatitis C virus (HCV)
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    Chapter 32 Folding of the mouse hepatitis virus spike protein and its association with the membrane protein
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    Chapter 33 Assembly and entry mechamisms of Semliki Forest virus
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    Chapter 34 The interactions of the flavivirus envelope proteins: implications for virus entry and release
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    Chapter 35 Coronavirus polyprotein processing.
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    Chapter 36 Processing of dengue type 4 and other flavivirus nonstructural proteins
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    Chapter 37 Nuclear targeting of Semliki Forest virus nsP2
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    Chapter 38 Replication and translation of cowpea mosaic virus RNAs are tightly linked
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    Chapter 39 Alphavirus positive and negative strand RNA synthesis and the role of polyproteins in formation of viral replication complexes
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    Chapter 40 Nodavirus RNA replication: mechanism and harnessing to vaccinia virus recombinants
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    Chapter 41 Molecular characterization of Borna virus RNA
  43. Altmetric Badge
    Chapter 42 Genomic organization and expression of astroviruses and caliciviruses
  44. Altmetric Badge
    Chapter 43 Lelystad virus belongs to a new virus family, comprising lactate dehydrogenase-elevating virus, equine arteritis virus, and simian hemorrhagic fever virus
  45. Altmetric Badge
    Chapter 44 Recognition of cellular receptors by bovine coronavirus
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    Chapter 45 Mouse hepatitis virus receptors: more than a single carcinoembryonic antigen.
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    Chapter 46 Host-cell receptors for Sindbis virus
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    Chapter 47 Cell surface receptor for ecotropic host-range mouse retroviruses: a cationic amino acid transporter.
  49. Altmetric Badge
    Chapter 48 Comparative studies of T = 3 and T = 4 icosahedral RNA insect viruses
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    Chapter 49 Retroviral RNA packaging: a review
  51. Altmetric Badge
    Chapter 50 Structural studies of viruses by electron cryomicroscopy
  52. Altmetric Badge
    Chapter 51 Crystallographic and cryo EM analysis of virion-receptor interactions
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    Chapter 52 Assembly of tobacco mosaic virus and TMV-like pseudovirus particles in Escherichia coli
Attention for Chapter 4: Age-dependent susceptibility to fatal encephalitis: alphavirus infection of neurons.
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Chapter title
Age-dependent susceptibility to fatal encephalitis: alphavirus infection of neurons.
Chapter number 4
Book title
Positive-Strand RNA Viruses
Published in
Archives of virology Supplementum, January 1994
DOI 10.1007/978-3-7091-9326-6_4
Pubmed ID
Book ISBNs
978-3-21-182522-8, 978-3-70-919326-6
Authors

Griffin, D E, Levine, B, Tyor, W R, Tucker, P C, Hardwick, J M, Griffin, D. E., Levine, B., Tyor, W. R., Tucker, P. C., Hardwick, J. M.

Abstract

Sindbis virus encephalitis in mice provides a model for studying age-dependent susceptibility to acute viral encephalitis. The AR339 strain of SV causes fatal encephalitis in newborn mice, but weanling mice recover uneventfully. Increased virulence for older mice is associated with a single amino acid change from Gln to His at position 55 of the E2 glycoprotein. Weanling mice with normal immune systems clear infectious virus from neurons through an antibody-mediated mechanism. This does not happen in newborn mice because the infected neurons die soon after they are infected. Death in immature neurons, as well as most other mammalian cells infected with Sindbis virus, occurs by induction of apoptosis. This can be prevented by cellular expression of bcl-2, an inhibitor of apoptosis, which is expressed by mature neurons in culture. We conclude that mature neurons are resistant to induction of apoptosis after infection with SV through expression of cellular inhibitors of apoptosis. This provides the opportunity for antibody to clear virus by a noncytolytic mechanism.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 20 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 35%
Researcher 5 25%
Professor 3 15%
Professor > Associate Professor 2 10%
Unspecified 1 5%
Other 2 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 8 40%
Immunology and Microbiology 3 15%
Biochemistry, Genetics and Molecular Biology 2 10%
Unspecified 1 5%
Psychology 1 5%
Other 2 10%
Unknown 3 15%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 June 2014.
All research outputs
#18,559,907
of 22,986,950 outputs
Outputs from Archives of virology Supplementum
#20
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Outputs of similar age
#69,189
of 71,420 outputs
Outputs of similar age from Archives of virology Supplementum
#2
of 2 outputs
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