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Positive-Strand RNA Viruses

Overview of attention for book
Cover of 'Positive-Strand RNA Viruses'

Table of Contents

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    Book Overview
  2. Altmetric Badge
    Chapter 1 The importance of antigenic variation in vaccine design
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    Chapter 2 The genetic and functional basis of HIV-1 resistance to nonnucleoside reverse transcriptase inhibitors.
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    Chapter 3 Structure-based design of symmetric inhibitors of HIV-1 protease
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    Chapter 4 Age-dependent susceptibility to fatal encephalitis: alphavirus infection of neurons.
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    Chapter 5 Principles and background for the construction of transgenic plants displaying multiple virus resistance
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    Chapter 6 The structure of an immunodominant loop on foot and mouth disease virus, serotype O1, determined under reducing conditions.
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    Chapter 7 Immunopathologic mechanisms of dengue hemorrhagic fever and dengue shock syndrome.
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    Chapter 8 Cardioviral poly(C) tracts and viral pathogenesis.
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    Chapter 9 Transgenic mice and the pathogenesis of poliomyelitis.
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    Chapter 10 Adaptation of positive-strand RNA viruses to plants
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    Chapter 11 A molecular genetic approach to the study of Venezuelan equine encephalitis virus pathogenesis
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    Chapter 12 Use of drug-resistance mutants to identify functional regions in picornavirus capsid proteins. - PubMed - NCBI
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    Chapter 13 Flock house virus: a simple model for studying persistent infection in cultured Drosophila cells.
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    Chapter 14 Protein-protein interactions and glycerophospholipids in bromovirus and nodavirus RNA replication
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    Chapter 15 Characteristics of the poliovirus replication complex
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    Chapter 16 Secretory pathway function, but not cytoskeletal integrity, is required in poliovirus infection.
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    Chapter 17 Role of subgenomic minus-strand RNA in coronavirus replication
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    Chapter 18 Common replication strategies emerging from the study of diverse groups of positive-strand RNA viruses
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    Chapter 19 Preferential replication of defective turnip yellow mosaic virus RNAs that express the 150-kDa protein in cis
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    Chapter 20 In vivo transfection by hepatitis A virus synthetic RNA.
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    Chapter 21 Recombination between Sindbis virus RNAs
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    Chapter 22 Homologous RNA recombination allows efficient introduction of site-specific mutations into the genome of coronavirus MHV-A59 via synthetic co-replicating RNAs
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    Chapter 23 Targeting of the site of nonhomologous genetic recombination in brome mosaic virus
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    Chapter 24 Natural recombination in bovine viral diarrhea viruses
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    Chapter 25 Sequences at the ends of RNA-2 of I6, a recombinant tobravirus
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    Chapter 26 Identification and characterization of host factor interactions with cis -acting elements of rubella virus RNA
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    Chapter 27 Interaction of cellular proteins with the poliovirus 5′ noncoding region
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    Chapter 28 IRES-controlled protein synthesis and genome replication of poliovirus.
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    Chapter 29 Analysis of hepatitis A virus translation in a T7 polymerase-expressing cell line
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    Chapter 30 Purification and characterization of the U-particle, a cellular constituent whose synthesis is stimulated by Mengovirus infection
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    Chapter 31 B-lymphocytes are predominantely involved in viral propagation of hepatitis C virus (HCV)
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    Chapter 32 Folding of the mouse hepatitis virus spike protein and its association with the membrane protein
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    Chapter 33 Assembly and entry mechamisms of Semliki Forest virus
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    Chapter 34 The interactions of the flavivirus envelope proteins: implications for virus entry and release
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    Chapter 35 Coronavirus polyprotein processing.
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    Chapter 36 Processing of dengue type 4 and other flavivirus nonstructural proteins
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    Chapter 37 Nuclear targeting of Semliki Forest virus nsP2
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    Chapter 38 Replication and translation of cowpea mosaic virus RNAs are tightly linked
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    Chapter 39 Alphavirus positive and negative strand RNA synthesis and the role of polyproteins in formation of viral replication complexes
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    Chapter 40 Nodavirus RNA replication: mechanism and harnessing to vaccinia virus recombinants
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    Chapter 41 Molecular characterization of Borna virus RNA
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    Chapter 42 Genomic organization and expression of astroviruses and caliciviruses
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    Chapter 43 Lelystad virus belongs to a new virus family, comprising lactate dehydrogenase-elevating virus, equine arteritis virus, and simian hemorrhagic fever virus
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    Chapter 44 Recognition of cellular receptors by bovine coronavirus
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    Chapter 45 Mouse hepatitis virus receptors: more than a single carcinoembryonic antigen.
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    Chapter 46 Host-cell receptors for Sindbis virus
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    Chapter 47 Cell surface receptor for ecotropic host-range mouse retroviruses: a cationic amino acid transporter.
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    Chapter 48 Comparative studies of T = 3 and T = 4 icosahedral RNA insect viruses
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    Chapter 49 Retroviral RNA packaging: a review
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    Chapter 50 Structural studies of viruses by electron cryomicroscopy
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    Chapter 51 Crystallographic and cryo EM analysis of virion-receptor interactions
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    Chapter 52 Assembly of tobacco mosaic virus and TMV-like pseudovirus particles in Escherichia coli
Attention for Chapter 8: Cardioviral poly(C) tracts and viral pathogenesis.
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (92nd percentile)

Mentioned by

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Chapter title
Cardioviral poly(C) tracts and viral pathogenesis.
Chapter number 8
Book title
Positive-Strand RNA Viruses
Published in
Archives of virology Supplementum, January 1994
DOI 10.1007/978-3-7091-9326-6_8
Pubmed ID
Book ISBNs
978-3-21-182522-8, 978-3-70-919326-6

A C Palmenberg, J E Osorio, Palmenberg, A. C., Osorio, J. E.


Mengovirus is a prototypical member of the cardiovirus genus of the family Picornaviridae. The positive-strand RNA genome is 7761 bases in length and encodes a polyprotein of 2293 amino acids. The 5' non-coding region (758 bases) contains an unusual homopolymeric poly(C) tract, which in the wild-type virus, has a sequence of C50UC10. We have discovered through genetic engineering that truncation or deletion of this poly(C) sequence yields infectious virus isolates that grow well in cell culture, but are 10(6) to 10(9) fold less pathogenic to mice than the wild type strain. Animals receiving sublethal doses of the short poly(C) strains characteristically develop high levels of neutralizing antibodies and acquire lifelong protective immunity against challenge with wild type virus. Effectively, the genetically engineered strains are superb vaccines against cardiovirus disease. Moreover, their potential is not limited to murine hosts. Pigs and sub-human primates have also been protectively vaccinated with short poly(C) tract Mengoviruses. The molecular mechanism of poly(C)-mediated pathogenesis is currently under study. Most hypotheses link the activity to induction of the antiviral cytokine, interferon.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 1 10%
Unknown 9 90%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 40%
Student > Bachelor 1 10%
Other 1 10%
Student > Doctoral Student 1 10%
Unknown 3 30%
Readers by discipline Count As %
Agricultural and Biological Sciences 3 30%
Biochemistry, Genetics and Molecular Biology 1 10%
Environmental Science 1 10%
Immunology and Microbiology 1 10%
Social Sciences 1 10%
Other 0 0%
Unknown 3 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 December 2013.
All research outputs
of 22,733,113 outputs
Outputs from Archives of virology Supplementum
of 23 outputs
Outputs of similar age
of 70,964 outputs
Outputs of similar age from Archives of virology Supplementum
of 2 outputs
Altmetric has tracked 22,733,113 research outputs across all sources so far. Compared to these this one has done well and is in the 81st percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 23 research outputs from this source. They receive a mean Attention Score of 3.2. This one scored the same or higher as 20 of them.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 70,964 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them