Chapter title |
Synthesis of O-Linked Glycoconjugates in the Nervous System
|
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Chapter number | 4 |
Book title |
Glycobiology of the Nervous System
|
Published in |
Advances in neurobiology, January 2014
|
DOI | 10.1007/978-1-4939-1154-7_4 |
Pubmed ID | |
Book ISBNs |
978-1-4939-1153-0, 978-1-4939-1154-7
|
Authors |
Jin-Ichi Inokuchi, Shinji Go, Yoshio Hirabayashi, Inokuchi, Jin-Ichi, Go, Shinji, Hirabayashi, Yoshio |
Abstract |
Glycoproteins carrying O-linked N-acetylgalactosamine, N-acetylgluco-samine, mannose, fucose, glucose, and xylose are found in the nervous system. Lipids can be glycosylated as well. Membrane lipid, ceramide, is modified by the addition of either glucose or galactose to form glycosphingolipid, galactosylceramide, or glucosylceramide. Recent analyses have identified glucosylated lipids of cholesterol and phosphatidic acid. These O-linked carbohydrate residues are found primarily on the outer surface of the plasma membrane or in the extracellular space. Their expression is cell or tissue specific and developmentally regulated. Due to their structural diversity, they play important roles in a variety of biological processes such as membrane transport and cell-cell interactions. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 3 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Professor | 1 | 33% |
Student > Ph. D. Student | 1 | 33% |
Other | 1 | 33% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 1 | 33% |
Agricultural and Biological Sciences | 1 | 33% |
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