Chapter title |
Chemistry and Function of Glycosaminoglycans in the Nervous System
|
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Chapter number | 5 |
Book title |
Glycobiology of the Nervous System
|
Published in |
Advances in neurobiology, January 2014
|
DOI | 10.1007/978-1-4939-1154-7_5 |
Pubmed ID | |
Book ISBNs |
978-1-4939-1153-0, 978-1-4939-1154-7
|
Authors |
Nancy B. Schwartz, Miriam S. Domowicz, Schwartz, Nancy B., Domowicz, Miriam S. |
Abstract |
The glycosaminoglycan (GAG) family is characterized by covalently linked repeating disaccharides forming long unbranched polysaccharide chains. Thus far in higher eukaryotes, the family consists of chondroitin sulfate (CS), heparin/heparan sulfate (HS), dermatan sulfate (DS), and hyaluronan (HA). All GAG chains (except HA) are characteristically modified by varying amounts of esterified sulfate. One or more GAG chains are usually found in nature bound to polypeptide backbones in the form of proteoglycans; HA is the exception and is not synthesized covalently bound to a protein. Proteoglycans, and especially their GAG components, participate in numerous biologically significant interactions with growth factors, chemokines, morphogens, guidance molecules, survival factors, and other extracellular and cell-surface components. These interactions are often critical to the basic developmental processes of cellular proliferation and differentiation, as well as to both the onset of disease sequelae and the prevention of disease progression. In the nervous system, GAG/proteoglycan-mediated interactions participate in proliferation and synaptogenesis, neural plasticity, and regeneration. This review focuses on the structure, chemistry, and function of GAGs in nervous system development, disease, and injury response. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 15 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Doctoral Student | 3 | 20% |
Student > Bachelor | 2 | 13% |
Student > Master | 2 | 13% |
Student > Ph. D. Student | 2 | 13% |
Professor > Associate Professor | 2 | 13% |
Other | 2 | 13% |
Unknown | 2 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 4 | 27% |
Biochemistry, Genetics and Molecular Biology | 3 | 20% |
Chemistry | 2 | 13% |
Veterinary Science and Veterinary Medicine | 1 | 7% |
Neuroscience | 1 | 7% |
Other | 1 | 7% |
Unknown | 3 | 20% |