| Chapter title |
Structural Analysis of Oligosaccharides and Glycoconjugates Using NMR
|
|---|---|
| Chapter number | 8 |
| Book title |
Glycobiology of the Nervous System
|
| Published in |
Advances in neurobiology, January 2014
|
| DOI | 10.1007/978-1-4939-1154-7_8 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-1153-0, 978-1-4939-1154-7
|
| Authors |
Yoshiki Yamaguchi, Takumi Yamaguchi, Koichi Kato, Yamaguchi, Yoshiki, Yamaguchi, Takumi, Kato, Koichi |
| Abstract |
Carbohydrate chains play critical roles in cellular recognition and subsequent signal transduction in the nervous system. Furthermore, gangliosides are targets for various amyloidogenic proteins associated with neurodegenerative disorders. To better understand the molecular mechanisms underlying these biological phenomena, atomic views are essential to delineate dynamic biomolecular interactions. Nuclear magnetic resonance (NMR) spectroscopy provides powerful tools for studying structures, dynamics, and interactions of biomolecules at the atomic level. This chapter describes the basics of solution NMR techniques and their applications to the analysis of 3D structures and interactions of glycoconjugates in the nervous system. |
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.