Chapter title |
Antibiotics Clinical Development and Pipeline.
|
---|---|
Chapter number | 451 |
Book title |
How to Overcome the Antibiotic Crisis
|
Published in |
Current topics in microbiology and immunology, July 2015
|
DOI | 10.1007/82_2015_451 |
Pubmed ID | |
Book ISBNs |
978-3-31-949282-7, 978-3-31-949284-1
|
Authors |
Hesterkamp, Thomas, Thomas Hesterkamp |
Abstract |
There is a constant need for resupply with resistance-breaking antibiotics. Governmental programs and updated regulatory guidance have incentivized mainly small- and medium-sized biopharmaceutical companies to develop novel antibiotics up to market licensure, while major pharma players, with exceptions, have abandoned the space for a perceived lack of a return on their investment. The portfolio of approved drugs has improved over recent years for gram-positive infections, including infections caused by methicillin-resistant Staphylococcus aureus. On the other hand, unmet medical need has surfaced in indications dominated by gram-negative pathogens including complicated intra-abdominal and bloodstream infections as well as hospital-acquired and ventilator-associated pneumonia. Few if any treatment options are left for extended-spectrum beta-lactamase- and carbapenemase-producing Enterobacteriaceae, e.g., Klebsiella pneumoniae, and the multi-drug-resistant non-fermenting gram-negative bacteria Pseudomonas aeruginosa and Acinetobacter baumannii. The present paper summarizes and reviews the clinical pipeline of novel antibiotics by clinical indication and identifies the unmet medical need in the space. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 63 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 11 | 17% |
Other | 8 | 13% |
Student > Ph. D. Student | 8 | 13% |
Student > Master | 7 | 11% |
Student > Bachelor | 4 | 6% |
Other | 9 | 14% |
Unknown | 16 | 25% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 13 | 21% |
Agricultural and Biological Sciences | 8 | 13% |
Immunology and Microbiology | 5 | 8% |
Biochemistry, Genetics and Molecular Biology | 4 | 6% |
Nursing and Health Professions | 3 | 5% |
Other | 7 | 11% |
Unknown | 23 | 37% |