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How to Overcome the Antibiotic Crisis

Overview of attention for book
Cover of 'How to Overcome the Antibiotic Crisis'

Table of Contents

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    Book Overview
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    Chapter 451 Antibiotics Clinical Development and Pipeline.
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    Chapter 490 Anti-virulence Strategies to Target Bacterial Infections
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    Chapter 491 Anti-infectives in Drug Delivery-Overcoming the Gram-Negative Bacterial Cell Envelope. - PubMed - NCBI
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    Chapter 492 Tackling Threats and Future Problems of Multidrug-Resistant Bacteria
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    Chapter 493 Strategies to Block Bacterial Pathogenesis by Interference with Motility and Chemotaxis
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    Chapter 494 Diagnostics and Resistance Profiling of Bacterial Pathogens
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    Chapter 495 New Horizons in the Development of Novel Needle-Free Immunization Strategies to Increase Vaccination Efficacy
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    Chapter 496 Exploitation of Fungal Biodiversity for Discovery of Novel Antibiotics
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    Chapter 497 Epidemiology of Staphylococcus aureus Nasal Carriage Patterns in the Community
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    Chapter 498 Strategies for the Discovery and Development of New Antibiotics from Natural Products: Three Case Studies
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    Chapter 499 History of Antibiotics Research
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    Chapter 501 New Structural Templates for Clinically Validated and Novel Targets in Antimicrobial Drug Research and Development
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    Chapter 502 Synthesis of Antibiotics
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    Chapter 503 Actinobacteria and Myxobacteria—Two of the Most Important Bacterial Resources for Novel Antibiotics
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    Chapter 504 Antibiotics and the Intestinal Microbiome : Individual Responses, Resilience of the Ecosystem, and the Susceptibility to Infections.
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    Chapter 505 Emergence and Spread of Antimicrobial Resistance: Recent Insights from Bacterial Population Genomics
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    Chapter 506 Use of Antibiotics and Antimicrobial Resistance in Veterinary Medicine as Exemplified by the Swine Pathogen Streptococcus suis
Attention for Chapter 499: History of Antibiotics Research
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#36 of 711)
  • High Attention Score compared to outputs of the same age (93rd percentile)

Mentioned by

news
3 news outlets
blogs
1 blog
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3 X users
facebook
2 Facebook pages
wikipedia
1 Wikipedia page

Citations

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28 Dimensions

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938 Mendeley
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Chapter title
History of Antibiotics Research
Chapter number 499
Book title
How to Overcome the Antibiotic Crisis
Published in
Current topics in microbiology and immunology, October 2016
DOI 10.1007/82_2016_499
Pubmed ID
Book ISBNs
978-3-31-949282-7, 978-3-31-949284-1
Authors

Mohr, Kathrin I, Kathrin I. Mohr, Mohr, Kathrin I.

Abstract

For thousands of years people were delivered helplessly to various kinds of infections, which often reached epidemic proportions and have cost the lives of millions of people. This is precisely the age since mankind has been thinking of infectious diseases and the question of their causes. However, due to a lack of knowledge, the search for strategies to fight, heal, and prevent the spread of communicable diseases was unsuccessful for a long time. It was not until the discovery of the healing effects of (antibiotic producing) molds, the first microscopic observations of microorganisms in the seventeenth century, the refutation of the abiogenesis theory, and the dissolution of the question "What is the nature of infectious diseases?" that the first milestones within the history of antibiotics research were set. Then new discoveries accelerated rapidly: Bacteria could be isolated and cultured and were identified as possible agents of diseases as well as producers of bioactive metabolites. At the same time the first synthetic antibiotics were developed and shortly thereafter, thousands of synthetic substances as well as millions of soil borne bacteria and fungi were screened for bioactivity within numerous microbial laboratories of pharmaceutical companies. New antibiotic classes with different targets were discovered as on assembly line production. With the beginning of the twentieth century, many of the diseases which reached epidemic proportions at the time-e.g., cholera, syphilis, plague, tuberculosis, or typhoid fever, just to name a few, could be combatted with new discovered antibiotics. It should be considered that hundred years ago the market launch of new antibiotics was significantly faster and less complicated than today (where it takes 10-12 years in average between the discovery of a new antibiotic until the launch). After the first euphoria it was quickly realized that bacteria are able to develop, acquire, and spread numerous resistance mechanisms. Whenever a new antibiotic reached the market it did not take long until scientists observed the first resistant germs. Since the marketing of the first antibiotic there is a neck-on-neck race between scientists who discover natural or develop semisynthetic and synthetic bioactive molecules and bacteria, which have developed resistance mechanisms. The emphasis of this chapter is to give an overview of the history of antibiotics research. The situation within the pre-antibiotic era as well as in the early antibiotic era will be described until the Golden Age of Antibiotics will conclude this time travel. The most important antibiotic classes, information about their discovery, activity spectrum, mode of action, resistance mechanisms, and current application will be presented.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 938 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 <1%
Unknown 937 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 162 17%
Student > Master 112 12%
Student > Ph. D. Student 79 8%
Researcher 46 5%
Student > Doctoral Student 36 4%
Other 82 9%
Unknown 421 45%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 153 16%
Medicine and Dentistry 66 7%
Agricultural and Biological Sciences 55 6%
Pharmacology, Toxicology and Pharmaceutical Science 52 6%
Immunology and Microbiology 50 5%
Other 115 12%
Unknown 447 48%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 35. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 May 2024.
All research outputs
#1,184,006
of 25,941,588 outputs
Outputs from Current topics in microbiology and immunology
#36
of 711 outputs
Outputs of similar age
#21,126
of 327,433 outputs
Outputs of similar age from Current topics in microbiology and immunology
#1
of 2 outputs
Altmetric has tracked 25,941,588 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 711 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.1. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 327,433 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them