Chapter title |
New Structural Templates for Clinically Validated and Novel Targets in Antimicrobial Drug Research and Development
|
---|---|
Chapter number | 501 |
Book title |
How to Overcome the Antibiotic Crisis
|
Published in |
Current topics in microbiology and immunology, January 2016
|
DOI | 10.1007/82_2016_501 |
Pubmed ID | |
Book ISBNs |
978-3-31-949282-7, 978-3-31-949284-1
|
Authors |
Philipp Klahn, Mark Brönstrup, Klahn, Philipp, Brönstrup, Mark |
Abstract |
The development of bacterial resistance against current antibiotic drugs necessitates a continuous renewal of the arsenal of efficacious drugs. This imperative has not been met by the output of antibiotic research and development of the past decades for various reasons, including the declining efforts of large pharma companies in this area. Moreover, the majority of novel antibiotics are chemical derivatives of existing structures that represent mostly step innovations, implying that the available chemical space may be exhausted. This review negates this impression by showcasing recent achievements in lead finding and optimization of antibiotics that have novel or unexplored chemical structures. Not surprisingly, many of the novel structural templates like teixobactins, lysocin, griselimycin, or the albicidin/cystobactamid pair were discovered from natural sources. Additional compounds were obtained from the screening of synthetic libraries and chemical synthesis, including the gyrase-inhibiting NTBI's and spiropyrimidinetrione, the tarocin and targocil inhibitors of wall teichoic acid synthesis, or the boronates and diazabicyclo[3.2.1]octane as novel β-lactamase inhibitors. A motif that is common to most clinically validated antibiotics is that they address hotspots in complex biosynthetic machineries, whose functioning is essential for the bacterial cell. Therefore, an introduction to the biological targets-cell wall synthesis, topoisomerases, the DNA sliding clamp, and membrane-bound electron transport-is given for each of the leads presented here. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 31 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 8 | 26% |
Researcher | 5 | 16% |
Student > Master | 3 | 10% |
Other | 2 | 6% |
Professor | 2 | 6% |
Other | 4 | 13% |
Unknown | 7 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Chemistry | 7 | 23% |
Agricultural and Biological Sciences | 4 | 13% |
Biochemistry, Genetics and Molecular Biology | 3 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 6% |
Immunology and Microbiology | 2 | 6% |
Other | 5 | 16% |
Unknown | 8 | 26% |