| Chapter title |
The Role of the Antioxidant Protein DJ-1 in Type 2 Diabetes Mellitus
|
|---|---|
| Chapter number | 11 |
| Book title |
DJ-1/PARK7 Protein
|
| Published in |
Advances in experimental medicine and biology, January 2017
|
| DOI | 10.1007/978-981-10-6583-5_11 |
| Pubmed ID | |
| Book ISBNs |
978-9-81-106582-8, 978-9-81-106583-5
|
| Authors |
Daniel Eberhard, Eckhard Lammert, Eberhard, Daniel, Lammert, Eckhard |
| Abstract |
Type 2 diabetes mellitus (T2DM) is a worldwide escalating health disorder resulting from insulin resistance and functional loss of insulin-producing beta cells that finally cause chronically elevated blood glucose concentrations. Here we review the role of ubiquitously expressed antioxidant protein DJ-1 in the pathogenesis of T2DM. In beta cells, DJ-1 protects against oxidative stress, endoplasmic reticulum stress, and streptozotocin- and cytokine-induced stress and preserves beta cell viability and insulin secretion. In skeletal muscle, DJ-1 controls energy metabolism and efficient fuel utilization, whereas in adipose tissue a role in adipogenesis and obesity-induced inflammation has been reported. This suggests that DJ-1 plays multiple roles in many cell types under metabolically challenging conditions as seen in obesity, insulin resistance, and T2DM. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 23 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 8 | 35% |
| Researcher | 5 | 22% |
| Student > Postgraduate | 3 | 13% |
| Student > Bachelor | 2 | 9% |
| Student > Master | 2 | 9% |
| Other | 1 | 4% |
| Unknown | 2 | 9% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 12 | 52% |
| Medicine and Dentistry | 2 | 9% |
| Agricultural and Biological Sciences | 2 | 9% |
| Neuroscience | 2 | 9% |
| Business, Management and Accounting | 1 | 4% |
| Other | 1 | 4% |
| Unknown | 3 | 13% |