Chapter title |
DJ-1 as a Therapeutic Target Against Cancer
|
---|---|
Chapter number | 13 |
Book title |
DJ-1/PARK7 Protein
|
Published in |
Advances in experimental medicine and biology, January 2017
|
DOI | 10.1007/978-981-10-6583-5_13 |
Pubmed ID | |
Book ISBNs |
978-9-81-106582-8, 978-9-81-106583-5
|
Authors |
Ji Cao, Xiaobing Chen, Meidan Ying, Qiaojun He, Bo Yang, Cao, Ji, Chen, Xiaobing, Ying, Meidan, He, Qiaojun, Yang, Bo |
Abstract |
DJ-1 is a gene involved in various cellular processes, including transcriptional regulation, oxidative stress response, fertilization, mitochondrial regulation, inflammatory and fibrogenic niche formation, and glycation damage prevention. Although a disease-associated genetic study within the past decade has demonstrated that the mutation of DJ-1 is associated with autosomal early-onset Parkinson's disease, increasing evidence suggests that DJ-1 also plays a critical role in tumor development and progression. In this review, we provide an overview of current knowledge concerning the role and the mechanism of DJ-1 in cancer and also discuss the possibility of DJ-1 as a therapeutic target against cancer. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 16 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 3 | 19% |
Student > Doctoral Student | 2 | 13% |
Student > Ph. D. Student | 2 | 13% |
Unspecified | 1 | 6% |
Student > Master | 1 | 6% |
Other | 2 | 13% |
Unknown | 5 | 31% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 3 | 19% |
Neuroscience | 2 | 13% |
Unspecified | 1 | 6% |
Arts and Humanities | 1 | 6% |
Agricultural and Biological Sciences | 1 | 6% |
Other | 3 | 19% |
Unknown | 5 | 31% |