Chapter title |
Transcriptional Regulation of DJ-1
|
---|---|
Chapter number | 7 |
Book title |
DJ-1/PARK7 Protein
|
Published in |
Advances in experimental medicine and biology, January 2017
|
DOI | 10.1007/978-981-10-6583-5_7 |
Pubmed ID | |
Book ISBNs |
978-9-81-106582-8, 978-9-81-106583-5
|
Authors |
Kazuko Takahashi-Niki, Takeshi Niki, Sanae M. M. Iguchi-Ariga, Hiroyoshi Ariga, Takahashi-Niki, Kazuko, Niki, Takeshi, Iguchi-Ariga, Sanae M. M., Ariga, Hiroyoshi |
Abstract |
DJ-1 is an oncogene and also a causative gene for familial Parkinson's disease. DJ-1 has various functions, and the oxidative status of a cysteine residue at position 106 (C106) is crucial for determination of the activation level of DJ-1.DJ-1 binds to many proteins, including various transcription factors, and acts as a coactivator or corepressor for regulating their target genes without direct binding to DNA, thereby affecting various cell functions. DJ-1-regulating transcription factors and their modified proteins are the androgen receptor and its regulatory proteins, p53; polypyrimidine tract-binding protein-associated splicing factor (PSF); Keap1, an inhibitor for nuclear factor erythroid2-related factor 2 (Nrf2); sterol regulatory element-binding protein (SREBP); Ras-responsive element-binding protein (RREB1); signal transducer and activator of transcription 1 (STAT1); and Nurr1. Considering oxidative stress response and dopamine synthesis, the regulation of Nrf2, p53, and PSF by DJ-1 is especially important. In addition, SREBP1 and RREB1 functions that are positively regulated by DJ-1 may participate in the onset and pathogenesis of metabolic syndrome.DJ-1 is expressed ubiquitously with high levels in the testis and brain and moderate levels in other tissues. Furthermore, DJ-1 is translocated from the cytoplasm to nucleus during the cell cycle after mitogen stimulation, suggesting that DJ-1 has a growth-related function. In this review, we describe how DJ-1 regulates cell growth/death and dopamine synthesis by targeting various transcription factors. |
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Student > Bachelor | 4 | 6% |
Student > Postgraduate | 4 | 6% |
Student > Doctoral Student | 3 | 4% |
Other | 8 | 12% |
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Immunology and Microbiology | 3 | 4% |
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