Chapter title |
An In Vitro Model of Traumatic Brain Injury
|
---|---|
Chapter number | 17 |
Book title |
Traumatic and Ischemic Injury
|
Published in |
Methods in molecular biology, January 2018
|
DOI | 10.1007/978-1-4939-7526-6_17 |
Pubmed ID | |
Book ISBNs |
978-1-4939-7524-2, 978-1-4939-7526-6
|
Authors |
Ellaine Salvador, Malgorzata Burek, Carola Y. Förster, Salvador, Ellaine, Burek, Malgorzata, Förster, Carola Y. |
Abstract |
Traumatic brain injury (TBI) is a significant problem causing high mortality globally. Methods to increase possibilities for treatment and prevention of secondary injuries resulting from the initial physical insult are thus much needed. TBI affects the central nervous system (CNS) and the neurovascular unit as a whole in numerous ways but one of the primarily compromised components is the blood-brain barrier (BBB).In this chapter, we present a detailed procedure on how stretch injury and oxygen-glucose deprivation (OGD) are applied to brain microvascular endothelial cells of the BBB in order to replicate the actual impact they receive during TBI. |
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Members of the public | 1 | 100% |
Mendeley readers
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Student > Master | 6 | 21% |
Student > Ph. D. Student | 5 | 17% |
Student > Bachelor | 3 | 10% |
Researcher | 3 | 10% |
Student > Doctoral Student | 2 | 7% |
Other | 4 | 14% |
Unknown | 6 | 21% |
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Agricultural and Biological Sciences | 2 | 7% |
Other | 4 | 14% |
Unknown | 6 | 21% |