| Chapter title |
An Ovine Model for Studying the Pathophysiology of Septic Acute Kidney Injury
|
|---|---|
| Chapter number | 16 |
| Book title |
Traumatic and Ischemic Injury
|
| Published in |
Methods in molecular biology, January 2018
|
| DOI | 10.1007/978-1-4939-7526-6_16 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-7524-2, 978-1-4939-7526-6
|
| Authors |
Yugeesh R. Lankadeva, Junko Kosaka, Roger G. Evans, Clive N. May, Lankadeva, Yugeesh R., Kosaka, Junko, Evans, Roger G., May, Clive N. |
| Abstract |
The development of acute kidney injury (AKI) is both a significant and independent prognostic factor of mortality in patients with sepsis, but its pathophysiology remains unclear. Herein, we describe an ovine model of sepsis evoked by the administration of live Escherichia coli in which there is hypotension, peripheral vasodilatation with a large increase in cardiac output; a similar hyperdynamic state to that commonly reported in humans. Interestingly, in this sheep model of sepsis, despite an increase in global kidney blood flow, there is a progressive reduction in renal function. Although renal hyperperfusion develops, renal tissue hypoxia due to redistribution of intrarenal blood flow may contribute to the pathogenesis of septic AKI. We have, therefore, developed a novel methodology to chronically implant combination probes to monitor intrarenal tissue perfusion and oxygen tension during the development of septic AKI in conscious sheep with hyperdynamic sepsis. |
X Demographics
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| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 50% |
| France | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Scientists | 1 | 50% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 14 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 3 | 21% |
| Researcher | 3 | 21% |
| Student > Master | 3 | 21% |
| Professor | 1 | 7% |
| Student > Doctoral Student | 1 | 7% |
| Other | 1 | 7% |
| Unknown | 2 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Nursing and Health Professions | 3 | 21% |
| Medicine and Dentistry | 3 | 21% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 14% |
| Veterinary Science and Veterinary Medicine | 2 | 14% |
| Engineering | 2 | 14% |
| Other | 0 | 0% |
| Unknown | 2 | 14% |