| Chapter title |
Laboratory-Scale Production of Replication-Deficient Adenovirus Vectored Vaccines
|
|---|---|
| Chapter number | 8 |
| Book title |
Vaccine Technologies for Veterinary Viral Diseases
|
| Published in |
Methods in molecular biology, January 2016
|
| DOI | 10.1007/978-1-4939-3008-1_8 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-3007-4, 978-1-4939-3008-1
|
| Authors |
Susan J. Morris, Alison V. Turner, Nicola Green, George M. Warimwe, Morris, Susan J., Turner, Alison V., Green, Nicola, Warimwe, George M. |
| Abstract |
Replication-deficient adenoviruses are potent vaccine development platforms used extensively for human and animal candidate vaccines, largely due to their very good safety and immunogenicity profile. In this chapter we describe a method that can be used in any laboratory for the scalable production of replication-deficient adenovirus vector vaccines to GLP for preclinical studies in animal models, including definitive experimental studies in large target animal species for veterinary applications. We use human adenovirus serotype 5 (HAdV5) as an example, but the method can be easily adapted for use with other adenovirus serotypes from different species of origin. |
X Demographics
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| Country | Count | As % |
|---|---|---|
| Mexico | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 16 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 4 | 25% |
| Student > Bachelor | 3 | 19% |
| Student > Ph. D. Student | 2 | 13% |
| Student > Doctoral Student | 1 | 6% |
| Professor | 1 | 6% |
| Other | 2 | 13% |
| Unknown | 3 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
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| Computer Science | 1 | 6% |
| Immunology and Microbiology | 1 | 6% |
| Other | 2 | 13% |
| Unknown | 6 | 38% |