Chapter title |
Laboratory-Scale Production of Replication-Deficient Adenovirus Vectored Vaccines
|
---|---|
Chapter number | 8 |
Book title |
Vaccine Technologies for Veterinary Viral Diseases
|
Published in |
Methods in molecular biology, January 2016
|
DOI | 10.1007/978-1-4939-3008-1_8 |
Pubmed ID | |
Book ISBNs |
978-1-4939-3007-4, 978-1-4939-3008-1
|
Authors |
Susan J. Morris, Alison V. Turner, Nicola Green, George M. Warimwe, Morris, Susan J., Turner, Alison V., Green, Nicola, Warimwe, George M. |
Abstract |
Replication-deficient adenoviruses are potent vaccine development platforms used extensively for human and animal candidate vaccines, largely due to their very good safety and immunogenicity profile. In this chapter we describe a method that can be used in any laboratory for the scalable production of replication-deficient adenovirus vector vaccines to GLP for preclinical studies in animal models, including definitive experimental studies in large target animal species for veterinary applications. We use human adenovirus serotype 5 (HAdV5) as an example, but the method can be easily adapted for use with other adenovirus serotypes from different species of origin. |
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