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Mendeley readers
| Chapter title |
The Rip1Tag2 Transgenic Mouse Model
|
|---|---|
| Chapter number | 14 |
| Book title |
Tumor Angiogenesis Assays
|
| Published in |
Methods in molecular biology, January 2016
|
| DOI | 10.1007/978-1-4939-3999-2_14 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-3997-8, 978-1-4939-3999-2
|
| Authors |
Ruben Bill, Gerhard Christofori |
| Abstract |
The Rip1Tag2 transgenic mouse model of β-cell carcinogenesis has been instrumental in studying various aspects of tumor angiogenesis and in investigating the response to anti-angiogenic therapeutics. Thereby, the in-depth assessment of blood and lymphatic vessel phenotypes and functionality represents key experimental analyses. In this chapter, we describe basic protocols to assess tumor blood vessel morphology (pericyte coverage), functionality (perfusion, leakiness, and hypoxia), lymphatic tumor coverage, and tumor cell proliferation and apoptosis based on immunofluorescence microscopy analysis. |
Mendeley readers
The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 10 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 4 | 40% |
| Student > Bachelor | 1 | 10% |
| Student > Postgraduate | 1 | 10% |
| Student > Doctoral Student | 1 | 10% |
| Unknown | 3 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 2 | 20% |
| Medicine and Dentistry | 2 | 20% |
| Agricultural and Biological Sciences | 1 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 10% |
| Unknown | 4 | 40% |