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Chemical Biology

Overview of attention for book
Cover of 'Chemical Biology'

Table of Contents

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    Book Overview
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    Chapter 1 Identification of therapeutic small-molecule leads in cultured cells using multiplexed pathway reporter readouts.
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    Chapter 2 Applying the logic of genetic interaction to discover small molecules that functionally interact with human disease alleles.
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    Chapter 3 Construction and application of a photo-cross-linked chemical array.
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    Chapter 4 High Content Screening for Modulators of Cardiac Differentiation in Human Pluripotent Stem Cells.
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    Chapter 5 Small-Molecule High-Throughput Screening Utilizing Xenopus Egg Extract.
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    Chapter 6 Fission Yeast-Based High-Throughput Screens for PKA Pathway Inhibitors and Activators.
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    Chapter 7 A Method for High-Throughput Analysis of Chronological Aging in Schizosaccharomyces pombe.
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    Chapter 8 Protocols for the Routine Screening of Drug Sensitivity in the Human Parasite Trichomonas vaginalis
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    Chapter 9 Chemical Genetic Screens Using Arabidopsis thaliana Seedlings Grown on Solid Medium
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    Chapter 10 Small-Molecule Screening Using Drosophila Models of Human Neurological Disorders.
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    Chapter 11 High-Throughput Small-Molecule Screening in Caenorhabditis elegans.
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    Chapter 12 Whole-Organism Screening for Modulators of Fasting Metabolism Using Transgenic Zebrafish
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    Chapter 13 High Content Screening for Modulators of Cardiovascular or Global Developmental Pathways in Zebrafish
  15. Altmetric Badge
    Chapter 14 Extraction Methods of Natural Products from Traditional Chinese Medicines
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    Chapter 15 Bioassay-Guided Identification of Bioactive Molecules from Traditional Chinese Medicines
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    Chapter 16 NMR screening in fragment-based drug design: a practical guide.
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    Chapter 17 Practical Strategies for Small-Molecule Probe Development in Chemical Biology
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    Chapter 18 Principal component analysis as a tool for library design: a case study investigating natural products, brand-name drugs, natural product-like libraries, and drug-like libraries.
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    Chapter 19 Small-Molecule Library Screening by Docking with PyRx.
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    Chapter 20 Fluorous Photoaffinity Labeling to Probe Protein-Small Molecule Interactions
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    Chapter 21 Identification of the Targets of Biologically Active Small Molecules Using Quantitative Proteomics.
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    Chapter 22 Drug Affinity Responsive Target Stability (DARTS) for Small-Molecule Target Identification.
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    Chapter 23 Chemical Genomic Profiling via Barcode Sequencing to Predict Compound Mode of Action.
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    Chapter 24 Image-Based Prediction of Drug Target in Yeast.
Attention for Chapter 8: Protocols for the Routine Screening of Drug Sensitivity in the Human Parasite Trichomonas vaginalis
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Chapter title
Protocols for the Routine Screening of Drug Sensitivity in the Human Parasite Trichomonas vaginalis
Chapter number 8
Book title
Chemical Biology
Published in
Methods in molecular biology, December 2014
DOI 10.1007/978-1-4939-2269-7_8
Pubmed ID
Book ISBNs
978-1-4939-2268-0, 978-1-4939-2269-7
Authors

Natto, Manal J., Eze, Anthonius A., de Koning, Harry P., Manal J. Natto, Anthonius A. Eze, Harry P. de Koning, Koning, Harry P. de, Koning, Harry P.

Abstract

Trichomonas vaginalis is a sexually transmitted protozoan parasite of humans. Treatment of trichomoniasis is almost completely dependent on the old drug metronidazole and is hampered by resistance. New drug development, like routine screening for drug resistance, has however been hampered by the lack of reliable screening protocols with sufficient throughput. Here we report on two separate in vitro protocols that use fluorescent dyes and allow for standardized drug sensitivity testing on the required scale.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 10 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 2 20%
Student > Ph. D. Student 2 20%
Student > Bachelor 1 10%
Lecturer > Senior Lecturer 1 10%
Lecturer 1 10%
Other 1 10%
Unknown 2 20%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 3 30%
Nursing and Health Professions 1 10%
Immunology and Microbiology 1 10%
Medicine and Dentistry 1 10%
Unknown 4 40%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 January 2015.
All research outputs
#20,251,039
of 22,780,165 outputs
Outputs from Methods in molecular biology
#9,870
of 13,093 outputs
Outputs of similar age
#296,009
of 353,203 outputs
Outputs of similar age from Methods in molecular biology
#627
of 992 outputs
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So far Altmetric has tracked 13,093 research outputs from this source. They receive a mean Attention Score of 3.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 992 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.