Chapter title |
Emerging Concepts in Innate Immunity
|
---|---|
Chapter number | 1 |
Book title |
Innate Immune Activation
|
Published in |
Methods in molecular biology, January 2018
|
DOI | 10.1007/978-1-4939-7519-8_1 |
Pubmed ID | |
Book ISBNs |
978-1-4939-7518-1, 978-1-4939-7519-8
|
Authors |
Karin Pelka, Dominic De Nardo |
Abstract |
This review introduces recent concepts in innate immunity highlighting some of the latest exciting findings. These include: the discovery of the initiator of pyroptosis, Gasdermin D, and mechanisms of inflammatory caspases in innate immune signaling; the formation of oligomeric signalosomes downstream of innate immune receptors; mechanisms that shape innate immune responses, such as cellular homeostasis, cell metabolism, and pathogen viability; rapid methods of cell-to-cell communication; the interplay between the host and its microbiome and the concept of innate immunological memory. Furthermore, we discuss open questions and illustrate how technological advances, such as CRISPR/Cas9, may provide important answers for outstanding questions in the field of innate immunity. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 50 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 13 | 26% |
Student > Bachelor | 8 | 16% |
Researcher | 6 | 12% |
Student > Ph. D. Student | 6 | 12% |
Professor | 3 | 6% |
Other | 6 | 12% |
Unknown | 8 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Immunology and Microbiology | 12 | 24% |
Biochemistry, Genetics and Molecular Biology | 11 | 22% |
Agricultural and Biological Sciences | 8 | 16% |
Medicine and Dentistry | 7 | 14% |
Unspecified | 1 | 2% |
Other | 3 | 6% |
Unknown | 8 | 16% |