| Chapter title |
Prolonged and Continuous Measurement of Kidney Oxygenation in Conscious Rats.
|
|---|---|
| Chapter number | 9 |
| Book title |
Kidney Research
|
| Published in |
Methods in molecular biology, January 2016
|
| DOI | 10.1007/978-1-4939-3353-2_9 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-3351-8, 978-1-4939-3353-2
|
| Authors |
Koeners, Maarten P, Ow, Connie P C, Russell, David M, Evans, Roger G, Malpas, Simon C, Koeners, Maarten P., Ow, Connie P. C., Russell, David M., Evans, Roger G., Malpas, Simon C., Maarten P. Koeners, Connie P. C. Ow, David M. Russell, Roger G. Evans, Simon C. Malpas |
| Editors |
Tim D. Hewitson, Edward R. Smith, Stephen G. Holt |
| Abstract |
A relative deficiency in kidney oxygenation, i.e., renal hypoxia, may contribute to the initiation and progression of acute and chronic kidney disease. A critical barrier to investigate this is the lack of methods allowing measurement of the partial pressure of oxygen in kidney tissue for long periods in vivo. We have developed, validated, and tested a novel telemetric method that can do this. Here we provide details on the calibration, implantation, implementation for data recording, and reuse of this telemetry-based technology for measurement of medullary tissue oxygen tension in conscious, unrestrained rats. This technique provides an important additional tool for investigating the impact of renal hypoxia in biology and pathophysiology. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 5 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 2 | 40% |
| Student > Bachelor | 1 | 20% |
| Other | 1 | 20% |
| Student > Master | 1 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 4 | 80% |
| Neuroscience | 1 | 20% |