Gastrointestinal Pharmacology
Springer, Cham
Chapter title |
Serotonergic Mechanisms Regulating the GI Tract: Experimental Evidence and Therapeutic Relevance
|
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Chapter number | 103 |
Book title |
Gastrointestinal Pharmacology
|
Published in |
Handbook of experimental pharmacology, January 2016
|
DOI | 10.1007/164_2016_103 |
Pubmed ID | |
Book ISBNs |
978-3-31-956359-6, 978-3-31-956360-2
|
Authors |
Natalie Terry, Kara Gross Margolis, Terry, Natalie, Margolis, Kara Gross |
Abstract |
Serotonin (5-hydroxytryptamine; 5-HT) is best known as a neurotransmitter critical for central nervous system (CNS) development and function. 95% of the body's serotonin, however, is produced in the intestine where it has been increasingly recognized for its hormonal, autocrine, paracrine, and endocrine actions. This chapter provides the most current knowledge of the critical autocrine and paracrine roles of 5-HT in intestinal motility and inflammation as well as its function as a hormone in osteocyte homeostasis. Therapeutic applications in each of these areas are also discussed. |
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