Chapter title |
Targeting c-di-GMP Signaling, Biofilm Formation, and Bacterial Motility with Small Molecules.
|
---|---|
Chapter number | 31 |
Book title |
c-di-GMP Signaling
|
Published in |
Methods in molecular biology, January 2017
|
DOI | 10.1007/978-1-4939-7240-1_31 |
Pubmed ID | |
Book ISBNs |
978-1-4939-7239-5, 978-1-4939-7240-1
|
Authors |
Opoku-Temeng, Clement, Sintim, Herman O, Clement Opoku-Temeng, Herman O. Sintim |
Abstract |
Bacteria possess several signaling molecules that regulate distinct phenotypes. Cyclic di-GMP (c-di-GMP) has emerged as a ubiquitous second messenger that regulates bacterial virulence, cell cycle, motility, and biofilm formation. The link between c-di-GMP signaling and biofilm formation affords novel strategies for treatment of biofilm-associated infections, which is a major public health problem. The complex c-di-GMP signaling pathway creates a hurdle in the development of small molecule modulators. Nonetheless, some progress has been made in this regard and inhibitors of c-di-GMP metabolizing enzymes that affect biofilm formation and motility have been documented. Herein we discuss the components of c-di-GMP signaling, their correlation with biofilm formation as well as motility and reported small molecule inhibitors of c-di-GMP signaling. |
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Members of the public | 1 | 100% |
Mendeley readers
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Unknown | 36 | 100% |
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Student > Ph. D. Student | 6 | 17% |
Researcher | 6 | 17% |
Student > Master | 5 | 14% |
Student > Bachelor | 4 | 11% |
Professor | 2 | 6% |
Other | 3 | 8% |
Unknown | 10 | 28% |
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Immunology and Microbiology | 1 | 3% |
Other | 1 | 3% |
Unknown | 11 | 31% |