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ErbB Receptor Signaling

Overview of attention for book
Cover of 'ErbB Receptor Signaling'

Table of Contents

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    Book Overview
  2. Altmetric Badge
    Chapter 1 ErbB Receptors and Cancer
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    Chapter 2 New Insights from Drosophila into the Regulation of EGFR Signaling
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    Chapter 3 C. elegans Vulva Induction: An In Vivo Model to Study Epidermal Growth Factor Receptor Signaling and Trafficking
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    Chapter 4 Targeting HER2 in Advanced Breast Cancer
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    Chapter 5 Methods to Investigate EGFR Ubiquitination
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    Chapter 6 Dimerization Assessment of Epithelial Growth Factor Family of Receptor Tyrosine Kinases by Using Cross-Linking Reagent
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    Chapter 7 Application of Immunofluorescence Staining to Study ErbB Family of Receptor Tyrosine Kinases
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    Chapter 8 Activation of Endosome-Associated Inert EGF Receptor Following Internalization
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    Chapter 9 Two-Pulse Endosomal Stimulation of Receptor Tyrosine Kinases Induces Cell Proliferation
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    Chapter 10 Study of EGFR Signaling/Endocytosis by Site-Directed Mutagenesis
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    Chapter 11 Using Percoll Gradient Fractionation to Study the Endocytic Trafficking of the EGFR
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    Chapter 12 Analysis of Epidermal Growth Factor Receptor-Induced Cell Motility by Wound Healing Assay
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    Chapter 13 Cell Cycle Synchronization of HeLa Cells to Assay EGFR Pathway Activation
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    Chapter 14 Analysis of Constitutive EGFR Signaling Regulating IRF3 Transcriptional Activity in Cancer Cells
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    Chapter 15 Measurement of Epidermal Growth Factor Receptor-Derived Signals Within Plasma Membrane Clathrin Structures
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    Chapter 16 Studying Nonproliferative Roles for Egfr Signaling in Tissue Morphogenesis Using Dorsal Closure of the Drosophila Embryo
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    Chapter 17 Analysis of Epithelial–Mesenchymal Transition Induced by Overexpression of Twist
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    Chapter 18 Assessment of Specificity of an Adenovirus Targeted to HER3/4
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    Chapter 19 Isolation of Human Mesenchymal Stem Cells for Studying ErbB Receptor Signaling
Attention for Chapter 3: C. elegans Vulva Induction: An In Vivo Model to Study Epidermal Growth Factor Receptor Signaling and Trafficking
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (69th percentile)
  • Good Attention Score compared to outputs of the same age and source (78th percentile)

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Chapter title
C. elegans Vulva Induction: An In Vivo Model to Study Epidermal Growth Factor Receptor Signaling and Trafficking
Chapter number 3
Book title
ErbB Receptor Signaling
Published in
Methods in molecular biology, January 2017
DOI 10.1007/978-1-4939-7219-7_3
Pubmed ID
Book ISBNs
978-1-4939-7218-0, 978-1-4939-7219-7
Authors

Kimberley Gauthier, Christian E. Rocheleau, Gauthier, Kimberley, Rocheleau, Christian E.

Abstract

Epidermal growth factor receptor (EGFR)-mediated activation of the canonical Ras/MAPK signaling cascade is responsible for cell proliferation and cell growth. This signaling pathway is frequently overactivated in epithelial cancers; therefore, studying regulation of this pathway is crucial not only for our fundamental understanding of cell biology but also for our ability to treat EGFR-related disease. Genetic model organisms such as Caenorhabditis elegans, a hermaphroditic nematode, played a vital role in identifying components of the EGFR/Ras/MAPK pathway and delineating their order of function, and continues to play a role in identifying novel regulators of the pathway. Polarized activation of LET-23, the C. elegans homolog of EGFR, is responsible for induction of the vulval cell fate; perturbations in this signaling pathway produce either a vulvaless or multivulva phenotype. The translucent cuticle of the nematode facilitates in vivo visualization of the receptor, revealing that localization of LET-23 EGFR is tightly regulated and linked to its function. In this chapter, we review the methods used to harness vulva development as a tool for studying EGFR signaling and trafficking in C. elegans.

X Demographics

X Demographics

The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 15 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 15 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 5 33%
Unspecified 2 13%
Student > Master 2 13%
Student > Ph. D. Student 1 7%
Researcher 1 7%
Other 1 7%
Unknown 3 20%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 3 20%
Unspecified 2 13%
Arts and Humanities 1 7%
Business, Management and Accounting 1 7%
Agricultural and Biological Sciences 1 7%
Other 3 20%
Unknown 4 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 April 2018.
All research outputs
#6,950,036
of 24,228,883 outputs
Outputs from Methods in molecular biology
#2,083
of 13,631 outputs
Outputs of similar age
#124,686
of 428,380 outputs
Outputs of similar age from Methods in molecular biology
#224
of 1,073 outputs
Altmetric has tracked 24,228,883 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 13,631 research outputs from this source. They receive a mean Attention Score of 3.5. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 428,380 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.
We're also able to compare this research output to 1,073 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.