Chapter title |
Automation of Technology for Cancer Research
|
---|---|
Chapter number | 14 |
Book title |
Cancer and Zebrafish
|
Published in |
Advances in experimental medicine and biology, May 2016
|
DOI | 10.1007/978-3-319-30654-4_14 |
Pubmed ID | |
Book ISBNs |
978-3-31-930652-0, 978-3-31-930654-4
|
Authors |
Wietske van der Ent, Wouter J. Veneman, Arwin Groenewoud, Lanpeng Chen, Claudia Tulotta, Pancras C. W. Hogendoorn, Herman. P. Spaink, B. Ewa Snaar-Jagalska |
Editors |
David M. Langenau |
Abstract |
Zebrafish embryos can be obtained for research purposes in large numbers at low cost and embryos develop externally in limited space, making them highly suitable for high-throughput cancer studies and drug screens. Non-invasive live imaging of various processes within the larvae is possible due to their transparency during development, and a multitude of available fluorescent transgenic reporter lines.To perform high-throughput studies, handling large amounts of embryos and larvae is required. With such high number of individuals, even minute tasks may become time-consuming and arduous. In this chapter, an overview is given of the developments in the automation of various steps of large scale zebrafish cancer research for discovering important cancer pathways and drugs for the treatment of human disease. The focus lies on various tools developed for cancer cell implantation, embryo handling and sorting, microfluidic systems for imaging and drug treatment, and image acquisition and analysis. Examples will be given of employment of these technologies within the fields of toxicology research and cancer research. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 15 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Professor | 4 | 27% |
Student > Doctoral Student | 2 | 13% |
Student > Bachelor | 2 | 13% |
Researcher | 2 | 13% |
Student > Master | 2 | 13% |
Other | 1 | 7% |
Unknown | 2 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 3 | 20% |
Agricultural and Biological Sciences | 2 | 13% |
Biochemistry, Genetics and Molecular Biology | 2 | 13% |
Chemical Engineering | 1 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 7% |
Other | 5 | 33% |
Unknown | 1 | 7% |