| Chapter title |
Uncharted Waters: Zebrafish Cancer Models Navigate a Course for Oncogene Discovery
|
|---|---|
| Chapter number | 1 |
| Book title |
Cancer and Zebrafish
|
| Published in |
Advances in experimental medicine and biology, May 2016
|
| DOI | 10.1007/978-3-319-30654-4_1 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-930652-0, 978-3-31-930654-4
|
| Authors |
Craig J. Ceol, Yariv Houvras |
| Editors |
David M. Langenau |
| Abstract |
Over a decade has elapsed since the first genetically-engineered zebrafish cancer model was described. During this time remarkable progress has been made. Sophisticated genetic tools have been built to generate oncogene expressing cancers and characterize multiple models of solid and blood tumors. These models have led to unique insights into mechanisms of tumor initiation and progression. New drug targets have been identified, particularly through the functional analysis of cancer genomes. Now in the second decade, zebrafish cancer models are poised for even faster growth as they are used in high-throughput genetic analyses to elucidate key mechanisms underlying critical cancer phenotypes. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 10 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 3 | 30% |
| Student > Master | 2 | 20% |
| Professor | 2 | 20% |
| Student > Doctoral Student | 1 | 10% |
| Student > Ph. D. Student | 1 | 10% |
| Other | 1 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 5 | 50% |
| Agricultural and Biological Sciences | 2 | 20% |
| Nursing and Health Professions | 1 | 10% |
| Medicine and Dentistry | 1 | 10% |
| Unknown | 1 | 10% |