Chapter title |
Imaging Cancer Angiogenesis and Metastasis in a Zebrafish Embryo Model
|
---|---|
Chapter number | 11 |
Book title |
Cancer and Zebrafish
|
Published in |
Advances in experimental medicine and biology, May 2016
|
DOI | 10.1007/978-3-319-30654-4_11 |
Pubmed ID | |
Book ISBNs |
978-3-31-930652-0, 978-3-31-930654-4
|
Authors |
C. Tulotta, S. He, W. van der Ent, L. Chen, A. Groenewoud, H. P. Spaink, B. E. Snaar-Jagalska, Tulotta, C., He, S., Ent, W., Chen, L., Groenewoud, A., Spaink, H. P., Snaar-Jagalska, B. E. |
Editors |
David M. Langenau |
Abstract |
Tumor angiogenesis and metastasis are key steps of cancer progression. In vitro and animal model studies have contributed to partially elucidating the mechanisms involved in these processes and in developing therapies. Besides the improvements in fundamental research and the optimization of therapeutic regimes, cancer still remains a major health threatening condition and therefore the development of new models is needed. The zebrafish is a powerful tool to study tumor angiogenesis and metastasis, because it allows the visualization of fluorescently labelled tumor cells inducing vessel remodeling, disseminating and invading surrounding tissues in a whole transparent embryo. The embryo model has also been used to address the contribution of the tumor stroma in sustaining tumor angiogenesis and spreading. Simultaneously, new anti-angiogenic drugs and compounds affecting malignant cell survival and migration can be tested by simply adding the compound into the water of living embryos. Therefore the zebrafish model offers the opportunity to gain more knowledge on cancer angiogenesis and metastasis in vivo with the final aim of providing new translational insights into therapeutic approaches to help patients. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 36 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 7 | 19% |
Student > Ph. D. Student | 7 | 19% |
Researcher | 4 | 11% |
Student > Bachelor | 4 | 11% |
Student > Doctoral Student | 3 | 8% |
Other | 3 | 8% |
Unknown | 8 | 22% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 12 | 33% |
Agricultural and Biological Sciences | 6 | 17% |
Engineering | 2 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
Materials Science | 1 | 3% |
Other | 1 | 3% |
Unknown | 13 | 36% |