Chapter title |
5'-AMP-Activated Protein Kinase Signaling in Caenorhabditis elegans.
|
---|---|
Chapter number | 15 |
Book title |
AMP-activated Protein Kinase
|
Published in |
EXS, November 2016
|
DOI | 10.1007/978-3-319-43589-3_15 |
Pubmed ID | |
Book ISBNs |
978-3-31-943587-9, 978-3-31-943589-3
|
Authors |
Moloud Ahmadi, Richard Roy |
Editors |
Mario D. Cordero, Benoit Viollet |
Abstract |
AMP-activated protein kinase (AMPK) is one of the central regulators of cellular and organismal metabolism in eukaryotes. Once activated by decreased energy levels, it induces ATP production by promoting catabolic pathways while conserving ATP by inhibiting anabolic pathways. AMPK plays a crucial role in various aspects of cellular function such as regulating growth, reprogramming metabolism, autophagy, and cell polarity. In this chapter, we focus on how recent breakthroughs made using the model organism Caenorhabditis elegans have contributed to our understanding of AMPK function and how it can be utilized in the future to elucidate hitherto unknown aspects of AMPK signaling. |
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