| Chapter title |
AMPK in Yeast: The SNF1 (Sucrose Non-fermenting 1) Protein Kinase Complex.
|
|---|---|
| Chapter number | 14 |
| Book title |
AMP-activated Protein Kinase
|
| Published in |
EXS, November 2016
|
| DOI | 10.1007/978-3-319-43589-3_14 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-943587-9, 978-3-31-943589-3
|
| Authors |
Pascual Sanz, Rosa Viana, Maria Adelaida Garcia-Gimeno |
| Editors |
Mario D. Cordero, Benoit Viollet |
| Abstract |
In yeast, SNF1 protein kinase is the orthologue of mammalian AMPK complex. It is a trimeric complex composed of Snf1 protein kinase (orthologue of AMPKα catalytic subunit), Snf4 (orthologue of AMPKγ regulatory subunit), and a member of the Gal83/Sip1/Sip2 family of proteins (orthologues of AMPKβ subunit) that act as scaffolds and also regulate the subcellular localization of the complex. In this chapter, we review the recent literature on the characteristics of SNF1 complex subunits, the structure and regulation of the activity of the SNF1 complex, its role at the level of transcriptional regulation of relevant target genes and also at the level of posttranslational modification of targeted substrates. We also review the crosstalk of SNF1 complex activity with other key protein kinase pathways such as cAMP-PKA, TORC1, and PAS kinase. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 52 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 9 | 17% |
| Student > Bachelor | 9 | 17% |
| Student > Master | 5 | 10% |
| Student > Doctoral Student | 4 | 8% |
| Researcher | 4 | 8% |
| Other | 9 | 17% |
| Unknown | 12 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 24 | 46% |
| Agricultural and Biological Sciences | 12 | 23% |
| Linguistics | 1 | 2% |
| Medicine and Dentistry | 1 | 2% |
| Chemistry | 1 | 2% |
| Other | 1 | 2% |
| Unknown | 12 | 23% |