Chapter title |
AMPK/Mitochondria in Metabolic Diseases.
|
---|---|
Chapter number | 6 |
Book title |
AMP-activated Protein Kinase
|
Published in |
EXS, November 2016
|
DOI | 10.1007/978-3-319-43589-3_6 |
Pubmed ID | |
Book ISBNs |
978-3-31-943587-9, 978-3-31-943589-3
|
Authors |
Pedro Bullon, Fabiola Marin-Aguilar, Lourdes Roman-Malo |
Editors |
Mario D. Cordero, Benoit Viollet |
Abstract |
The obtaining of nutrients is the most important task in our lives. Energy is central to life's evolutions; this was one of the aspect that induced the selection of the more adaptable and more energetically profitable species. Nowadays things have changed in our modern society. A high proportion of people has access to plenty amount of food and the obesity appear as one of the pathological characteristics of our society. Energy is obtained essentially in the mitochondria with the transfer of protons across the inner membrane that produce ATP. The exactly regulation of the synthesis and degradation of ATP (ATP ↔ ADP + phosphate) is essential to all form of life. This task is performed by the 5' adenosine monophosphate-activated protein kinase (AMPK). mtDNA is highly exposed to oxidative damage and could play a central role in human health and disease. This high potential rate of abnormalities is controlled by one of the most complex mechanism: the autophagy. AMPK appears to be the key cellular energy sensor involved in multiple cellular mechanisms and is essential to have a good metabolic homeostasis to face all the aggression and start the inflammatory reaction. Therefore its disturbances have been related with multiple diseases. Recent findings support the role of AMPK in inflammation and immunity such as Metabolic Syndrome, Obesity and Diabetes. All these Metabolic Disorders are considered pandemics and they need an adequate control and prevention. One important way to achieve it is deepen in the pathogenic mechanisms. Mitochondria and AMPK are the key elements through which it happen, their knowledge and research allow us to a better management. The discovery and use of drugs that can modulate them is imperative to improve our way of manage the metabolic disorders. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 36 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 7 | 19% |
Researcher | 5 | 14% |
Student > Postgraduate | 4 | 11% |
Student > Ph. D. Student | 4 | 11% |
Professor > Associate Professor | 3 | 8% |
Other | 4 | 11% |
Unknown | 9 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 8 | 22% |
Medicine and Dentistry | 3 | 8% |
Nursing and Health Professions | 3 | 8% |
Agricultural and Biological Sciences | 2 | 6% |
Computer Science | 2 | 6% |
Other | 6 | 17% |
Unknown | 12 | 33% |