| Chapter title |
AMPK Regulation of Cell Growth, Apoptosis, Autophagy, and Bioenergetics.
|
|---|---|
| Chapter number | 3 |
| Book title |
AMP-activated Protein Kinase
|
| Published in |
EXS, November 2016
|
| DOI | 10.1007/978-3-319-43589-3_3 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-943587-9, 978-3-31-943589-3
|
| Authors |
Marina Villanueva Paz, David Cotán, Juan Garrido Maraver, Manuel Oropesa-Ávila, Mario de la Mata, Ana Delgado Pavón, Isabel de Lavera, Elizabet Alcocer Gómez, Mónica Álvarez Córdoba, José A. Sánchez Alcázar, Marina Villanueva-Paz, Juan Garrido-Maraver, Ana Delgado-Pavón, Elizabet Alcocer-Gómez, Mónica Álvarez-Córdoba, José A. Sánchez-Alcázar |
| Editors |
Mario D. Cordero, Benoit Viollet |
| Abstract |
In eukaryotic cells, AMP-activated protein kinase (AMPK) generally promotes catabolic pathways that produce ATP and at the same time inhibits anabolic pathways involved in different processes that consume ATP. As an energy sensor, AMPK is involved in the main cellular functions implicated in cell fate, such as cell growth and autophagy.Recently, AMPK has been connected with apoptosis regulation, although the molecular mechanism by which AMPK induces and/or inhibits cell death is not clear.This chapter reviews the essential role of AMPK in signaling pathways that respond to cellular stress and damage, highlighting the complex and reciprocal regulation between AMPK and their targets and effectors. The therapeutic implications of the role of AMPK in different pathologies such as diabetes, cancer, or mitochondrial dysfunctions are still controversial, and it is necessary to further investigate the molecular mechanisms underlying AMPK activation. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 50 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 9 | 18% |
| Researcher | 9 | 18% |
| Student > Master | 8 | 16% |
| Student > Bachelor | 3 | 6% |
| Student > Doctoral Student | 2 | 4% |
| Other | 7 | 14% |
| Unknown | 12 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 10 | 20% |
| Medicine and Dentistry | 6 | 12% |
| Agricultural and Biological Sciences | 5 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
| Immunology and Microbiology | 2 | 4% |
| Other | 8 | 16% |
| Unknown | 17 | 34% |