Chapter title |
AMP-activated Protein Kinase
|
---|---|
Chapter number | 5 |
Book title |
AMP-activated Protein Kinase
|
Published in |
EXS, November 2016
|
DOI | 10.1007/978-3-319-43589-3_5 |
Pubmed ID | |
Book ISBNs |
978-3-31-943587-9, 978-3-31-943589-3
|
Authors |
Kjøbsted, Rasmus, Wojtaszewski, Jørgen F P, Treebak, Jonas T, Rasmus Kjøbsted, Jørgen F. P. Wojtaszewski, Jonas T. Treebak |
Editors |
Mario D. Cordero, Benoit Viollet |
Abstract |
Skeletal muscle insulin resistance precedes development of type 2 diabetes (T2D). As skeletal muscle is a major sink for glucose disposal, understanding the molecular mechanisms involved in maintaining insulin sensitivity of this tissue could potentially benefit millions of people that are diagnosed with insulin resistance. Regular physical activity in both healthy and insulin-resistant individuals is recognized as the single most effective intervention to increase whole-body insulin sensitivity and thereby positively affect glucose homeostasis. A single bout of exercise has long been known to increase glucose disposal in skeletal muscle in response to physiological insulin concentrations. While this effect is identified to be restricted to the previously exercised muscle, the molecular basis for an apparent convergence between exercise- and insulin-induced signaling pathways is incompletely known. In recent years, we and others have identified the Rab GTPase-activating protein, TBC1 domain family member 4 (TBC1D4) as a target of key protein kinases in the insulin- and exercise-activated signaling pathways. Our working hypothesis is that the AMP-activated protein kinase (AMPK) is important for the ability of exercise to insulin sensitize skeletal muscle through TBC1D4. Here, we aim to provide an overview of the current available evidence linking AMPK to post-exercise insulin sensitivity. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 2 | 40% |
United Kingdom | 1 | 20% |
Unknown | 2 | 40% |
Demographic breakdown
Type | Count | As % |
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Scientists | 3 | 60% |
Members of the public | 2 | 40% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 43 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 8 | 19% |
Student > Master | 7 | 16% |
Student > Bachelor | 4 | 9% |
Researcher | 4 | 9% |
Professor > Associate Professor | 3 | 7% |
Other | 8 | 19% |
Unknown | 9 | 21% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 8 | 19% |
Sports and Recreations | 7 | 16% |
Agricultural and Biological Sciences | 4 | 9% |
Nursing and Health Professions | 2 | 5% |
Psychology | 2 | 5% |
Other | 9 | 21% |
Unknown | 11 | 26% |