Chapter title |
Cancer and Zebrafish
|
---|---|
Chapter number | 15 |
Book title |
Cancer and Zebrafish
|
Published in |
Advances in experimental medicine and biology, May 2016
|
DOI | 10.1007/978-3-319-30654-4_15 |
Pubmed ID | |
Book ISBNs |
978-3-31-930652-0, 978-3-31-930654-4
|
Authors |
Harrison, Nicholas R, Laroche, Fabrice J F, Gutierrez, Alejandro, Feng, Hui, Nicholas R. Harrison, Fabrice J. F. Laroche, Alejandro Gutierrez, Hui Feng |
Editors |
David M. Langenau |
Abstract |
Insights concerning leukemic pathophysiology have been acquired in various animal models and further efforts to understand the mechanisms underlying leukemic treatment resistance and disease relapse promise to improve therapeutic strategies. The zebrafish (Danio rerio) is a vertebrate organism with a conserved hematopoietic program and unique experimental strengths suiting it for the investigation of human leukemia. Recent technological advances in zebrafish research including efficient transgenesis, precise genome editing, and straightforward transplantation techniques have led to the generation of a number of leukemia models. The transparency of the zebrafish when coupled with improved lineage-tracing and imaging techniques has revealed exquisite details of leukemic initiation, progression, and regression. With these advantages, the zebrafish represents a unique experimental system for leukemic research and additionally, advances in zebrafish-based high-throughput drug screening promise to hasten the discovery of novel leukemia therapeutics. To date, investigators have accumulated knowledge of the genetic underpinnings critical to leukemic transformation and treatment resistance and without doubt, zebrafish are rapidly expanding our understanding of disease mechanisms and helping to shape therapeutic strategies for improved outcomes in leukemic patients. |
X Demographics
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 2% |
Unknown | 50 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 10 | 20% |
Student > Ph. D. Student | 7 | 14% |
Student > Master | 6 | 12% |
Student > Postgraduate | 5 | 10% |
Professor | 3 | 6% |
Other | 8 | 16% |
Unknown | 12 | 24% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 14 | 27% |
Medicine and Dentistry | 9 | 18% |
Agricultural and Biological Sciences | 6 | 12% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 8% |
Unspecified | 1 | 2% |
Other | 5 | 10% |
Unknown | 12 | 24% |