| Chapter title |
Influence of Thyroid Hormones on Tendon Homeostasis
|
|---|---|
| Chapter number | 12 |
| Book title |
Metabolic Influences on Risk for Tendon Disorders
|
| Published in |
Advances in experimental medicine and biology, August 2016
|
| DOI | 10.1007/978-3-319-33943-6_12 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-933941-2, 978-3-31-933943-6
|
| Authors |
Francesco Oliva, Eleonora Piccirilli, Anna C. Berardi, Umberto Tarantino, Nicola Maffulli, Oliva, Francesco, Piccirilli, Eleonora, Berardi, Anna C., Tarantino, Umberto, Maffulli, Nicola |
| Editors |
Paul W. Ackermann, David A. Hart |
| Abstract |
Tendinopathies have a multifactorial etiology driven by extrinsic and intrinsic factors. Recent studies have elucidated the importance of thyroid hormones in the alteration of tendons homeostasis and in the failure of tendon healing after injury. The effects of thyroid hormones are mediated by receptors (TR)-α and -β that seem to be ubiquitous. In particular, T3 and T4 play an antiapoptotic role on tenocytes, causing an increase in vital tenocytes isolated from tendons in vitro and a reduction of apoptotic ones; they are also able to influence extra cellular matrix proteins secretion in vitro from tenocytes, enhancing collagen production. From a clinical point of view, disorders of thyroid function have been investigated only for rotator cuff calcific tendinopathy and tears. In this complex scenario, further research is needed to clarify the role of thyroid hormones on the onset of tendinopathies. |
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Mendeley readers
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