Chapter title |
Inflammasome Signaling and Bacterial Infections
|
---|---|
Chapter number | 7 |
Book title |
Inflammasome Signaling and Bacterial Infections
|
Published in |
Current topics in microbiology and immunology, January 2016
|
DOI | 10.1007/978-3-319-41171-2_7 |
Pubmed ID | |
Book ISBNs |
978-3-31-941170-5, 978-3-31-941171-2
|
Authors |
Theisen, Erin, Sauer, John-Demian, Erin Theisen, John-Demian Sauer |
Abstract |
Inflammasomes are cytosolic innate immune surveillance systems that recognize a variety of danger signals, including those from pathogens. Listeria monocytogenes is a Gram-positive intracellular bacterium evolved to live within the harsh environment of the host cytosol. Further, L. monocytogenes can activate a robust cell-mediated immune response that is being harnessed as an immunotherapeutic platform. Access to the cytosol is critical for both causing disease and inducing a protective immune response, and it is hypothesized that the cytosolic innate immune system, including the inflammasome, is critical for both host protection and induction of long-term immunity. L. monocytogenes can activate a variety of inflammasomes via its pore-forming toxin listeriolysin-O, flagellin, or DNA released through bacteriolysis; however, inflammasome activation attenuates L. monocytogenes, and as such, L. monocytogenes has evolved a variety of ways to limit inflammasome activation. Surprisingly, inflammasome activation also impairs the host cell-mediated immune response. Thus, understanding how L. monocytogenes activates or avoids detection by the inflammasome is critical to understand the pathogenesis of L. monocytogenes and improve the cell-mediated immune response generated to L. monocytogenes for more effective immunotherapies. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 43 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 10 | 23% |
Researcher | 6 | 14% |
Student > Bachelor | 5 | 12% |
Professor > Associate Professor | 3 | 7% |
Student > Master | 3 | 7% |
Other | 6 | 14% |
Unknown | 10 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 11 | 26% |
Agricultural and Biological Sciences | 10 | 23% |
Immunology and Microbiology | 7 | 16% |
Nursing and Health Professions | 1 | 2% |
Business, Management and Accounting | 1 | 2% |
Other | 1 | 2% |
Unknown | 12 | 28% |