Chapter title |
Regulation of Tissue-Specific Alternative Splicing: C. elegans as a Model System
|
---|---|
Chapter number | 10 |
Book title |
RNA Processing
|
Published in |
Advances in experimental medicine and biology, January 2016
|
DOI | 10.1007/978-3-319-29073-7_10 |
Pubmed ID | |
Book ISBNs |
978-3-31-929071-3, 978-3-31-929073-7
|
Authors |
Xicotencatl Gracida, Adam D. Norris, John A. Calarco, Gracida, Xicotencatl, Norris, Adam D., Calarco, John A. |
Abstract |
Alternative pre-mRNA splicing serves as an elegant mechanism for generating transcriptomic and proteomic diversity between cell and tissue types. In this chapter, we highlight key concepts and outstanding goals in studies of tissue and cell-specific alternative splicing. We place particular emphasis on the use of C. elegans as a tractable model organism for in vivo studies of alternative splicing between tissues and also at single cell resolution. We describe our current understanding of tissue and cell-specific regulation in the animal, and emerging techniques that will allow for future mechanistic studies as well as systems level investigations of spatio-temporal splicing under laboratory conditions and in response to environmental stimuli. |
X Demographics
Geographical breakdown
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United Kingdom | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 20 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 7 | 35% |
Researcher | 3 | 15% |
Student > Bachelor | 2 | 10% |
Professor | 2 | 10% |
Other | 1 | 5% |
Other | 2 | 10% |
Unknown | 3 | 15% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 8 | 40% |
Biochemistry, Genetics and Molecular Biology | 7 | 35% |
Neuroscience | 1 | 5% |
Unknown | 4 | 20% |