Chapter title |
RNA Processing
|
---|---|
Chapter number | 11 |
Book title |
RNA Processing
|
Published in |
Advances in experimental medicine and biology, June 2016
|
DOI | 10.1007/978-3-319-29073-7_11 |
Pubmed ID | |
Book ISBNs |
978-3-31-929071-3, 978-3-31-929073-7
|
Authors |
Fan, Alexander C, Leung, Anthony K L, Fan, Alexander C., Leung, Anthony K. L., Alexander C. Fan, Anthony K. L. Leung |
Abstract |
RNA granules are microscopically visible cellular structures that aggregate by protein-protein and protein-RNA interactions. Using stress granules as an example, we discuss the principles of RNA granule formation, which rely on the multivalency of RNA and multi-domain proteins as well as low-affinity interactions between proteins with prion-like/low-complexity domains (e.g. FUS and TDP-43). We then explore how dysregulation of RNA granule formation is linked to neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD), and discuss possible strategies for therapeutic intervention. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 33% |
France | 1 | 17% |
Unknown | 3 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 83% |
Scientists | 1 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 1% |
Unknown | 81 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 22 | 27% |
Researcher | 11 | 13% |
Student > Bachelor | 10 | 12% |
Student > Master | 5 | 6% |
Student > Postgraduate | 4 | 5% |
Other | 11 | 13% |
Unknown | 19 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 30 | 37% |
Neuroscience | 15 | 18% |
Agricultural and Biological Sciences | 10 | 12% |
Medicine and Dentistry | 3 | 4% |
Philosophy | 1 | 1% |
Other | 2 | 2% |
Unknown | 21 | 26% |