Chapter title |
The MultiBac Baculovirus/Insect Cell Expression Vector System for Producing Complex Protein Biologics.
|
---|---|
Chapter number | 13 |
Book title |
Advanced Technologies for Protein Complex Production and Characterization
|
Published in |
Advances in experimental medicine and biology, May 2016
|
DOI | 10.1007/978-3-319-27216-0_13 |
Pubmed ID | |
Book ISBNs |
978-3-31-927214-6, 978-3-31-927216-0
|
Authors |
Duygu Sari, Kapil Gupta, Deepak Balaji Thimiri Govinda Raj, Alice Aubert, Petra Drncová, Frederic Garzoni, Daniel Fitzgerald, Imre Berger, Sari, Duygu, Gupta, Kapil, Raj, Deepak Balaji Thimiri Govinda, Aubert, Alice, Drncová, Petra, Garzoni, Frederic, Fitzgerald, Daniel, Berger, Imre |
Editors |
M. Cristina Vega |
Abstract |
Multiprotein complexes regulate most if not all cellular functions. Elucidating the structure and function of these complex cellular machines is essential for understanding biology. Moreover, multiprotein complexes by themselves constitute powerful reagents as biologics for the prevention and treatment of human diseases. Recombinant production by the baculovirus/insect cell expression system is particularly useful for expressing proteins of eukaryotic origin and their complexes. MultiBac, an advanced baculovirus/insect cell system, has been widely adopted in the last decade to produce multiprotein complexes with many subunits that were hitherto inaccessible, for academic and industrial research and development. The MultiBac system, its development and numerous applications are presented. Future opportunities for utilizing MultiBac to catalyze discovery are outlined. |
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