Chapter title |
Detection of C-Peptide in Urine as a Measure of Ongoing Beta Cell Function
|
---|---|
Chapter number | 330 |
Book title |
Type-1 Diabetes
|
Published in |
Methods in molecular biology, April 2016
|
DOI | 10.1007/7651_2016_330 |
Pubmed ID | |
Book ISBNs |
978-1-4939-3641-0, 978-1-4939-3643-4
|
Authors |
McDonald, Timothy J., Perry, Mandy H., McDonald, T J, Perry, M H, T. J. McDonald, M. H. Perry |
Editors |
Kathleen M. Gillespie |
Abstract |
C-peptide is a protein secreted by the pancreatic beta cells in equimolar quantities with insulin, following the cleavage of proinsulin into insulin. Measurement of C-peptide is used as a surrogate marker of endogenous insulin secretory capacity. Assessing C-peptide levels can be useful in classifying the subtype of diabetes as well as assessing potential treatment choices in the management of diabetes.Standard measures of C-peptide involve blood samples collected either fasted or, most often, after a fixed stimulus (such as oral glucose, mixed meal, or IV glucagon). Despite the established clinical utility of blood C-peptide measurement, its widespread use is limited. In many instances this is due to perceived practical restrictions associated with sample collection.Urine C-peptide measurement is an attractive noninvasive alternative to blood measures of beta-cell function. Urine C-peptide creatinine ratio measured in a single post stimulated sample has been shown to be a robust, reproducible measure of endogenous C-peptide which is stable for three days at room temperature when collected in boric acid. Modern high sensitivity immunoassay technologies have facilitated measurement of C-peptide down to single picomolar concentrations. |
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