Chapter title |
Type 1 Diabetes: Current Perspectives.
|
---|---|
Chapter number | 289 |
Book title |
Type-1 Diabetes
|
Published in |
Methods in molecular biology, December 2015
|
DOI | 10.1007/7651_2015_289 |
Pubmed ID | |
Book ISBNs |
978-1-4939-3641-0, 978-1-4939-3643-4
|
Authors |
Aizhan Kozhakhmetova, Kathleen M. Gillespie |
Editors |
Kathleen M. Gillespie |
Abstract |
Type 1 diabetes, resulting from the autoimmune destruction of insulin producing islet beta cells is caused by genetic and environmental determinants. Recent studies agree that counterintuitively, the major genetic susceptibility factors are decreasing in frequency as the incidence of the condition increases. This suggests a growing role for environmental determinants but these have been difficult to identify and our understanding of gene/environment effects are limited. Individuals "at risk" can be identified accurately through the presence of multiple islet autoantibodies and current efforts in type 1 diabetes research focus on improved biomarkers and strategies to prevent or reverse the condition through immunotherapy. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 16 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 6 | 38% |
Student > Master | 3 | 19% |
Student > Doctoral Student | 2 | 13% |
Unknown | 5 | 31% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 5 | 31% |
Nursing and Health Professions | 3 | 19% |
Agricultural and Biological Sciences | 1 | 6% |
Earth and Planetary Sciences | 1 | 6% |
Unknown | 6 | 38% |