Chapter title |
Optogenetic Light Crafting Tools for the Control of Cardiac Arrhythmias
|
---|---|
Chapter number | 20 |
Book title |
Optogenetics
|
Published in |
Methods in molecular biology, March 2016
|
DOI | 10.1007/978-1-4939-3512-3_20 |
Pubmed ID | |
Book ISBNs |
978-1-4939-3510-9, 978-1-4939-3512-3
|
Authors |
Claudia Richter, Jan Christoph, Stephan E. Lehnart, Stefan Luther |
Editors |
Arash Kianianmomeni |
Abstract |
The control of spatiotemporal dynamics in biological systems is a fundamental problem in nonlinear sciences and has important applications in engineering and medicine. Optogenetic tools combined with advanced optical technologies provide unique opportunities to develop and validate novel approaches to control spatiotemporal complexity in neuronal and cardiac systems. Understanding of the mechanisms and instabilities underlying the onset, perpetuation, and control of cardiac arrhythmias will enable the development and translation of novel therapeutic approaches. Here we describe in detail the preparation and optical mapping of transgenic channelrhodopsin-2 (ChR2) mouse hearts, cardiac cell cultures, and the optical setup for photostimulation using digital light processing. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 1 | 5% |
Unknown | 21 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 7 | 32% |
Researcher | 3 | 14% |
Student > Bachelor | 2 | 9% |
Professor | 2 | 9% |
Other | 2 | 9% |
Other | 5 | 23% |
Unknown | 1 | 5% |
Readers by discipline | Count | As % |
---|---|---|
Engineering | 4 | 18% |
Neuroscience | 4 | 18% |
Agricultural and Biological Sciences | 3 | 14% |
Medicine and Dentistry | 3 | 14% |
Biochemistry, Genetics and Molecular Biology | 2 | 9% |
Other | 2 | 9% |
Unknown | 4 | 18% |