| Chapter title |
Cancer Drug Resistance: A Brief Overview from a Genetic Viewpoint
|
|---|---|
| Chapter number | 1 |
| Book title |
Cancer Drug Resistance
|
| Published in |
Methods in molecular biology, January 2016
|
| DOI | 10.1007/978-1-4939-3347-1_1 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-3345-7, 978-1-4939-3347-1
|
| Authors |
Rueff, José, Rodrigues, António Sebastião, José Rueff, António Sebastião Rodrigues |
| Editors |
Jose Rueff, António Sebastião Rodrigues |
| Abstract |
Cancer drug resistance leading to therapeutic failure in the treatment of many cancers encompasses various mechanisms and may be intrinsic relying on the patient's genetic makeup or be acquired by tumors that are initially sensitive to cancer drugs. All in all, it may be responsible for treatment failure in over 90 % of patients with metastatic cancer. Cancer drug resistance, in particular acquired resistance, may stem from the micro-clonality/micro-genetic heterogeneity of the tumors whereby, among others, the following mechanisms may entail resistance: altered expression of drug influx/efflux transporters in the tumor cells mediating lower drug uptake and/or greater efflux of the drug; altered role of DNA repair and impairment of apoptosis; role of epigenomics/epistasis by methylation, acetylation, and altered levels of microRNAs leading to alterations in upstream or downstream effectors; mutation of drug targets in targeted therapy and alterations in the cell cycle and checkpoints; and tumor microenvironment that are briefly reviewed. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 117 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 18 | 15% |
| Student > Bachelor | 15 | 13% |
| Student > Ph. D. Student | 10 | 9% |
| Researcher | 8 | 7% |
| Professor > Associate Professor | 6 | 5% |
| Other | 20 | 17% |
| Unknown | 40 | 34% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 26 | 22% |
| Pharmacology, Toxicology and Pharmaceutical Science | 10 | 9% |
| Agricultural and Biological Sciences | 9 | 8% |
| Chemistry | 9 | 8% |
| Immunology and Microbiology | 6 | 5% |
| Other | 12 | 10% |
| Unknown | 45 | 38% |