Cancer Drug Resistance
Springer New York
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Timeline
Mendeley readers
| Chapter title |
Clinical and Molecular Methods in Drug Development: Neoadjuvant Systemic Therapy in Breast Cancer as a Model.
|
|---|---|
| Chapter number | 15 |
| Book title |
Cancer Drug Resistance
|
| Published in |
Methods in molecular biology, January 2016
|
| DOI | 10.1007/978-1-4939-3347-1_15 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-3345-7, 978-1-4939-3347-1
|
| Authors |
Sofia Braga |
| Editors |
José Rueff, António Sebastião Rodrigues |
| Abstract |
Neoadjuvant chemotherapy (NACT), neoadjuvant endocrine therapy (NAET), and neoadjuvant targeted therapy (NATT), more recently, have been adopted worldwide as standard of care in locally advanced and inoperable BC. These modalities, collectively called neoadjuvant systemic therapy (NAST), are also used for organ preservation and for mechanistic biological studies on drug response and resistance, drug development, and clinical trials. Furthermore, the response to NACT is a valuable indicator of long-term survival. In this work, the advantages and pitfalls of using NAST in BC for studying drug response and resistance for drug development and clinical trials are discussed as well as practical points on how to set up a NAST clinical trial in BC. |
Mendeley readers
The data shown below were compiled from readership statistics for 12 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Chile | 1 | 8% |
| Germany | 1 | 8% |
| Unknown | 10 | 83% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 2 | 17% |
| Student > Doctoral Student | 2 | 17% |
| Librarian | 1 | 8% |
| Student > Bachelor | 1 | 8% |
| Lecturer | 1 | 8% |
| Other | 3 | 25% |
| Unknown | 2 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 3 | 25% |
| Agricultural and Biological Sciences | 2 | 17% |
| Nursing and Health Professions | 1 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 8% |
| Design | 1 | 8% |
| Other | 0 | 0% |
| Unknown | 4 | 33% |