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Cell-Penetrating Peptides

Overview of attention for book
Cover of 'Cell-Penetrating Peptides'

Table of Contents

  1. Altmetric Badge
    Book Overview
  2. Altmetric Badge
    Chapter 1 Classes of Cell-Penetrating Peptides.
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    Chapter 2 Cell-Penetrating Peptides
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    Chapter 3 Prediction of Cell-Penetrating Peptides
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    Chapter 4 Computer-Aided Virtual Screening and Designing of Cell-Penetrating Peptides.
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    Chapter 5 Investigating Membrane Interactions and Structures of CPPs.
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    Chapter 6 Determining the Effects of Membrane-Interacting Peptides on Membrane Integrity.
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    Chapter 7 Study of CPP Mechanisms by Mass Spectrometry.
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    Chapter 8 Methods to Study the Role of the Glycocalyx in the Uptake of Cell-Penetrating Peptides
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    Chapter 9 Toxicity, Immunogenicity, Uptake, and Kinetics Methods for CPPs
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    Chapter 10 Unraveling the Mechanisms of Peptide-Mediated Delivery of Nucleic Acids Using Electron Microscopy.
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    Chapter 11 SCARA Involvement in the Uptake of Nanoparticles Formed by Cell-Penetrating Peptides
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    Chapter 12 Protein Mimicry and the Design of Bioactive Cell-Penetrating Peptides.
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    Chapter 13 Pepducins and Other Lipidated Peptides as Mechanistic Probes and Therapeutics.
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    Chapter 14 Identification and Characterization of Homing Peptides Using In Vivo Peptide Phage Display.
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    Chapter 15 The Antimicrobial and Antiviral Applications of Cell-Penetrating Peptides
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    Chapter 16 Visualizing Actin Architectures in Cells Incubated with Cell-Penetrating Peptides.
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    Chapter 17 Cell-Penetrating Peptides as Carriers for Transepithelial Drug Delivery In Vitro.
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    Chapter 18 A Pathway Toward Tumor Cell-Selective CPPs?
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    Chapter 19 PepFects and NickFects for the Intracellular Delivery of Nucleic Acids
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    Chapter 20 In Vitro Assays to Assess Exon Skipping in Duchenne Muscular Dystrophy.
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    Chapter 21 Applications of ApoB LDLR-Binding Domain Approach for the Development of CNS-Penetrating Peptides for Alzheimer's Disease.
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    Chapter 22 CPP-Based Delivery System for In Vivo Gene Delivery
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    Chapter 23 Application of CPPs for Brain Delivery
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    Chapter 24 Intracellular Delivery of Nanoparticles with Cell Penetrating Peptides.
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    Chapter 25 Cell-Penetrating Peptides
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    Chapter 26 Cell Penetrating Peptides for Chemical Biological Studies.
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    Chapter 27 Experiences with CPP-Based Self Assembling Peptide Systems for Topical Delivery of Botulinum Toxin.
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    Chapter 28 Applications of CPPs in Genome Modulation of Plants.
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    Chapter 29 DNA Transfer into Animal Cells Using Stearylated CPP Based Transfection Reagent.
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    Chapter 30 Live Cell Genomics: Cell-Specific Transcriptome Capture in Live Tissues and Cells.
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    Chapter 31 Live Cell Genomics: RNA Exon-Specific RNA-Binding Protein Isolation.
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    Chapter 32 ERRATUM TO: Methods to Study the Role of the Glycocalyx in the Uptake of Cell-Penetrating Peptides.
Attention for Chapter 8: Methods to Study the Role of the Glycocalyx in the Uptake of Cell-Penetrating Peptides
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Chapter title
Methods to Study the Role of the Glycocalyx in the Uptake of Cell-Penetrating Peptides
Chapter number 8
Book title
Cell-Penetrating Peptides
Published in
Methods in molecular biology, January 2015
DOI 10.1007/978-1-4939-2806-4_8
Pubmed ID
26202266
Book ISBNs
978-1-4939-2805-7, 978-1-4939-2806-4
Authors

Samuel Schmidt, Rike Wallbrecher, Toin H van Kuppevelt, Roland Brock, Toin H. van Kuppevelt, Schmidt, Samuel, Wallbrecher, Rike, Kuppevelt, Toin H., Brock, Roland

Editors

Ülo Langel

Abstract

Cells are covered by a layer of negatively charged oligo- and polysaccharides, the glycocalyx. Cell-penetrating peptides and other drug delivery vehicles first encounter these polyanions before contacting the lipid bilayer of the plasma membrane. While a large body of data supports the notion that interactions with the glycocalyx promote or even trigger uptake, in some cases, the glycocalyx compromises delivery. As a consequence there is a need to address the role of the glycocalyx in delivery for each specific delivery vehicle and for each particular type of cell. Here, we describe protocols to obtain information on the composition and dynamics of the glycocalyx, and the role of individual glycocalyx components in the uptake of drug delivery vehicles.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
 Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 13 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 13 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 3 23%
Student > Ph. D. Student 2 15%
Unspecified 1 8%
Professor 1 8%
Student > Doctoral Student 1 8%
Other 2 15%
Unknown 3 23%
Readers by discipline Count As %
Chemistry 3 23%
Agricultural and Biological Sciences 3 23%
Unspecified 1 8%
Pharmacology, Toxicology and Pharmaceutical Science 1 8%
Biochemistry, Genetics and Molecular Biology 1 8%
Other 2 15%
Unknown 2 15%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 December 2015.
All research outputs
#18,431,664
of 22,834,308 outputs
Outputs from Methods in molecular biology
#7,920
of 13,126 outputs
Outputs of similar age
#255,931
of 353,198 outputs
Outputs of similar age from Methods in molecular biology
#481
of 997 outputs
Altmetric has tracked 22,834,308 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,126 research outputs from this source. They receive a mean Attention Score of 3.4. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
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We're also able to compare this research output to 997 others from the same source and published within six weeks on either side of this one. This one is in the 36th percentile – i.e., 36% of its contemporaries scored the same or lower than it.

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