Chapter title |
Order and Disorder in the Replicative Complex of Paramyxoviruses.
|
---|---|
Chapter number | 12 |
Book title |
Intrinsically Disordered Proteins Studied by NMR Spectroscopy
|
Published in |
Advances in experimental medicine and biology, September 2015
|
DOI | 10.1007/978-3-319-20164-1_12 |
Pubmed ID | |
Book ISBNs |
978-3-31-920163-4, 978-3-31-920164-1
|
Authors |
Erales, Jenny, Blocquel, David, Habchi, Johnny, Beltrandi, Matilde, Gruet, Antoine, Dosnon, Marion, Bignon, Christophe, Longhi, Sonia, Jenny Erales, David Blocquel, Johnny Habchi, Matilde Beltrandi, Antoine Gruet, Marion Dosnon, Christophe Bignon, Sonia Longhi |
Abstract |
In this review we summarize available data showing the abundance of structural disorder within the nucleoprotein (N) and phosphoprotein (P) from three paramyxoviruses, namely the measles (MeV), Nipah (NiV) and Hendra (HeV) viruses. We provide a detailed description of the molecular mechanisms that govern the disorder-to-order transition that the intrinsically disordered C-terminal domain (NTAIL) of their N proteins undergoes upon binding to the C-terminal X domain (XD) of the homologous P proteins. We also show that a significant flexibility persists within NTAIL-XD complexes, which therefore provide illustrative examples of "fuzziness". The functional implications of structural disorder for viral transcription and replication are discussed in light of the ability of disordered regions to establish a complex molecular partnership and to confer a considerable reach to the elements of the replicative machinery. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 15 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 3 | 20% |
Student > Master | 3 | 20% |
Other | 1 | 7% |
Lecturer | 1 | 7% |
Student > Bachelor | 1 | 7% |
Other | 3 | 20% |
Unknown | 3 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Veterinary Science and Veterinary Medicine | 3 | 20% |
Biochemistry, Genetics and Molecular Biology | 3 | 20% |
Agricultural and Biological Sciences | 3 | 20% |
Nursing and Health Professions | 1 | 7% |
Medicine and Dentistry | 1 | 7% |
Other | 1 | 7% |
Unknown | 3 | 20% |