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Intrinsically Disordered Proteins Studied by NMR Spectroscopy

Overview of attention for book
Intrinsically Disordered Proteins Studied by NMR Spectroscopy
Springer International Publishing

Table of Contents

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    Book Overview
  2. Altmetric Badge
    Chapter 1 Back to the Future: Nuclear Magnetic Resonance and Bioinformatics Studies on Intrinsically Disordered Proteins.
  3. Altmetric Badge
    Chapter 2 Structure and Dynamics of Intrinsically Disordered Proteins.
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    Chapter 3 NMR Methods for the Study of Instrinsically Disordered Proteins Structure, Dynamics, and Interactions: General Overview and Practical Guidelines
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    Chapter 4 Ensemble Calculation for Intrinsically Disordered Proteins Using NMR Parameters
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    Chapter 5 NMR Spectroscopic Studies of the Conformational Ensembles of Intrinsically Disordered Proteins.
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    Chapter 6 Recombinant Intrinsically Disordered Proteins for NMR: Tips and Tricks.
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    Chapter 7 Biophysical Methods to Investigate Intrinsically Disordered Proteins: Avoiding an "Elephant and Blind Men" Situation.
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    Chapter 8 Application of SAXS for the Structural Characterization of IDPs
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    Chapter 9 Bioinformatics Approaches for Predicting Disordered Protein Motifs
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    Chapter 10 Towards Understanding Protein Disorder In-Cell
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    Chapter 11 The Protein Ensemble Database
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    Chapter 12 Order and Disorder in the Replicative Complex of Paramyxoviruses.
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    Chapter 13 Druggability of Intrinsically Disordered Proteins.
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    Chapter 14 Beta Amyloid Hallmarks: From Intrinsically Disordered Proteins to Alzheimer's Disease.
Attention for Chapter 7: Biophysical Methods to Investigate Intrinsically Disordered Proteins: Avoiding an "Elephant and Blind Men" Situation.
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  • High Attention Score compared to outputs of the same age and source (80th percentile)

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Chapter title
Biophysical Methods to Investigate Intrinsically Disordered Proteins: Avoiding an "Elephant and Blind Men" Situation.
Chapter number 7
Book title
Intrinsically Disordered Proteins Studied by NMR Spectroscopy
Published in
Advances in experimental medicine and biology, January 2015
DOI 10.1007/978-3-319-20164-1_7
Pubmed ID
Book ISBNs
978-3-31-920163-4, 978-3-31-920164-1
Authors

Uversky, Vladimir N, Vladimir N. Uversky, Uversky, Vladimir N.

Abstract

Intrinsically disordered proteins (IDPs) and hybrid proteins possessing ordered domains and intrinsically disordered protein regions (IDPRs) are highly abundant in various proteomes. They are different from ordered proteins at many levels, and an unambiguous representation of an IDP structure is a difficult task. In fact, IDPs show an extremely wide diversity in their structural properties, being able to attain extended conformations (random coil-like) or to remain globally collapsed (molten globule-like). Disorder can differently affect different parts of a protein, with some regions being more ordered than others. IDPs and IDPRs exist as dynamic ensembles, resembling "protein-clouds". IDP structures are best presented as conformational ensembles that contain highly dynamic structures interconverting on a number of timescales. The determination of a unique high-resolution structure is not possible for an isolated IDP, and a detailed structural and dynamic characterization of IDPs cannot typically be provided by a single tool. Therefore, accurate descriptions of IDPs/IDPRs rely on a multiparametric approach that includes a host of biophysical methods that can provide information on the overall compactness of IDPs and their conformational stability, shape, residual secondary structure, transient long-range contacts, regions of restricted or enhanced mobility, etc. The goal of this chapter is to provide a brief overview of some of the components of this multiparametric approach.

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Mendeley readers

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The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 29 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 34%
Researcher 5 17%
Student > Master 2 7%
Professor > Associate Professor 2 7%
Student > Doctoral Student 1 3%
Other 1 3%
Unknown 8 28%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 10 34%
Engineering 3 10%
Chemistry 3 10%
Pharmacology, Toxicology and Pharmaceutical Science 1 3%
Computer Science 1 3%
Other 3 10%
Unknown 8 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 February 2018.
All research outputs
#6,962,193
of 22,829,083 outputs
Outputs from Advances in experimental medicine and biology
#1,114
of 4,952 outputs
Outputs of similar age
#95,692
of 353,131 outputs
Outputs of similar age from Advances in experimental medicine and biology
#53
of 272 outputs
Altmetric has tracked 22,829,083 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 4,952 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 353,131 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 272 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.