| Chapter title |
Molecular Dynamics Simulation of a Feather-Boa Model of a Bacterial Chromosome
|
|---|---|
| Chapter number | 20 |
| Book title |
Bacterial Chromatin
|
| Published in |
Methods in molecular biology, August 2018
|
| DOI | 10.1007/978-1-4939-8675-0_20 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-8674-3, 978-1-4939-8675-0
|
| Authors |
Debasish Chaudhuri, Bela M. Mulder, Chaudhuri, Debasish, Mulder, Bela M. |
| Abstract |
The chromosome of a bacterium consists of a mega-base pair long circular DNA, which self-organizes within the micron-sized bacterial cell volume, compacting itself by three orders of magnitude. Unlike in eukaryotes, it lacks a nuclear membrane, and freely floats in the cytosol confined by the cell membrane. It is believed that strong confinement, cross-linking by associated proteins, and molecular crowding all contribute to determine chromosome size and morphology. Modeling the chromosome simply as a circular polymer decorated with closed side-loops in a cylindrical confining volume, has been shown to already recapture some of the salient properties observed experimentally. Here, we describe how a computer simulation can be set up to study structure and dynamics of bacterial chromosomes using this model. |
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