Chapter title |
Low-Temperature Deposition Modeling of β-TCP Scaffolds with Controlled Bimodal Porosity
|
---|---|
Chapter number | 4 |
Book title |
Biomaterials for Tissue Engineering
|
Published in |
Methods in molecular biology, January 2018
|
DOI | 10.1007/978-1-4939-7741-3_4 |
Pubmed ID | |
Book ISBNs |
978-1-4939-7739-0, 978-1-4939-7741-3
|
Authors |
E. Papastavrou, P. Breedon, D. Fairhurst |
Abstract |
Low-temperature deposition modeling (LDM), otherwise termed freeze-form extrusion fabrication or rapid freeze prototyping, involves dispensing an aqueous-based ceramic paste or polymeric hydrogel along predefined paths in subzero ambient temperatures, followed by freeze-drying. The solidification of the material after the deposition of each layer enables large parts to be built without the need for organic binders, which can often have cytotoxic effects. Freeze-dried parts obtained from LDM typically exhibit pores with openings that range in average between 1 and 40 μm. The technique offers the ability to control their size distribution and orientation through varying a number of processing and material parameters. Herein, we describe the construction of an LDM system from readily available electromechanical components, as well as the preparation of a β-ΤCP paste formulation with the appropriate flow characteristics for fabricating hierarchical scaffolds with tailorable bimodal porosity for applications in bone tissue engineering. |
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